Ekspresi protein pada pasien tuberkulosis kanker jaringan kelenjar getah bening dan non kelenjar getah bening
DOI: https://doi.org/10.56922/pti.v6i2.3681
CD4 Immunohistochemistry Lymph Node Tissue Tuberculosis
Abstract
Background: Mycobacterium tuberculosis in patients with tuberculosis has mechanisms that induce tumor formation and contribute to the development of cancer. In more than 80% of cases, TB primarily affects the lungs and other tissues, leading to chronic inflammation. Inflammation has long been associated with the development of cancer. T lymphocytes from patients with active tuberculosis secrete high levels of vascular endothelial growth factor (VEGF). VEGF is also secreted by CD4+ T lymphocytes treated with purified tuberculin protein derivative (PPD).
Purpose: To determine protein expression in tuberculosis patients with lymph node and non-lymph node TB tissue.
Method: This experimental study employed immunohistochemistry. Data were analyzed using one-way ANOVA followed by the Tukey HSD test. Research data were statistically analyzed using the Mann–Whitney test.
Results: Non-lymph node tuberculosis exhibits a lower cellular immune response, with the H-score method providing an accurate quantitative assessment of CD4 expression.
Conclusion: CD4 protein expression based on H-score was significantly higher in lymph node tuberculosis.
Suggestion: Further research correlating CD4 expression with other specific immune biomarkers is needed to clarify the immune response profile in tuberculosis.
Keywords: CD4; Immunohistochemistry; Lymph Node; Tissue; Tuberculosis.
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