Evaluasi potensi interaksi obat pada pasien rawat inap penderita hipertensi dengan sindrom metabolik
DOI: https://doi.org/10.56922/pti.v6i2.3426
Drug Interactions Hypertension Hospitalization Metabolic Syndrome Polypharmacy
Abstract
Background: Hypertension with metabolic syndrome is a condition that often requires combination therapy, thus increasing the risk of drug interactions.
Purpose: To determine the potential for drug interactions and factors related to the occurrence of drug interactions in hospitalized patients with hypertension and metabolic syndrome.
Method: Using an observational method with a cross-sectional design, the study sample consisted of 121 respondents. Data analysis was performed using univariate analysis to describe respondent characteristics, bivariate analysis using the Chi-Square and Mann-Whitney tests to determine the relationship between variables, and multivariate analysis using logistic regression to determine the factors most influential on drug interaction events.
Results: Bivariate analysis showed that the number of medications significantly correlated with drug interactions (p-value = 0.026), while gender, age, and length of stay did not (p-value > 0.05). Multivariate analysis showed that the number of medications tended to be the most influential factor in drug interactions, with an OR of 1.262 and a p-value of 0.074.
Conclusion: The number of medications is the most influential factor influencing the occurrence of drug interactions in hypertensive patients with metabolic syndrome. The more medications a patient takes, the greater the risk of drug interactions. Therefore, regular monitoring of medication use and evaluation of therapy are necessary to improve the safety and effectiveness of patient therapy.
Keywords: Drug Interactions; Hypertension; Hospitalization; Metabolic Syndrome; Polypharmacy.
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References
Agustina, R., Annisa, N., & Prabowo, W. C. (2015). Potensi interaksi obat resep pasien hipertensi di salah satu rumah sakit pemerintah di kota Samarinda. Jurnal sains dan Kesehatan, 1(4), 208-213.
Akbar, Z., Rehman, S., Khan, A., Khan, A., Atif, M., & Ahmad, N. (2021). Potential drug–drug interactions in patients with cardiovascular diseases: findings from a prospective observational study. Journal of Pharmaceutical Policy and Practice, 14(1), 63.
Decroli, E. (2019). Diabetes Melitus Tipe 2. Padang: Pusat Penerbitan Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas. ISBN No. Di Poliklinik Geriatri Rsud Ulin Banjarmasin.
DeFronzo, R. A. (2015). Pathogenesis of type 2 diabetes mellitus. International textbook of diabetes mellitus, 371-400.
Indonesia, P. N. (2018). 11th Report of Indonesian renal registry 2018. Jakarta: Perhimpunan Nefrologi Indonesia, 1-46.
Kementerian Kesehatan Republik Indonesia. (2019). Laporan Nasional Riset Kesehatan Dasar 2018. Badan Penelitian Dan Pengembangan Kesehatan: Diakses dari: https://archive.org/details/LaporanRiskesdas2018-NasionalPromkes.net
Kementerian Kesehatan Republik Indonesia. (2024). Bahaya Hipertensi, Upaya Pencegahan dan Pengendalian Hipertensi. Diakses dari: https://kemkes.go.id/id/rilis-kesehatan/bahaya-hipertensi-upaya-pencegahan-dan-pengendalian-hipertensi
Kusuma, A. S., Kristiani, E., Kusuma, A. S., & Kristiani, E. (2021). Pengaruh Teknik Relaksasi Autogenik Terhadap Penurunan Tekanan Darah Pasien Hipertensi. Jurnal Kesehatan, 10(1), 44-48.
Lestari, P. (2021). Faktor-faktor yang berhubungan dengan kejadian hipertensi di puskesmas kabupaten magelang (Doctoral dissertation, Skripsi, Universitas Muhammadiyah Magelang).
Maher, R. L., Hanlon, J., & Hajjar, E. R. (2014). Clinical consequences of polypharmacy in elderly. Expert opinion on drug safety, 13(1), 57-65.
Nuraisyah, F., & Kusumo, H. R. (2021). Edukasi Pencegahan dan Penanganan Hipertensi untuk Meningkatkan Kualitas Hidup pada Lansia. BAKTI: Jurnal Pengabdian Kepada Masyarakat, 1(2), 35-38.
Ogurtsova, K., Guariguata, L., Barengo, N. C., Ruiz, P. L. D., Sacre, J. W., Karuranga, S., & Magliano, D. J. (2022). IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes research and clinical practice, 183, 109118.
Pambudi, A. (2019). Hubungan Perilaku CERDIK dengan Derajat Hipertensi pada Pasien Hipertensi di Puskesmas Pandanwangi kota Malang (Doctoral dissertation, Universitas Brawijaya).
Saklayen, M. G. (2018). The global epidemic of the metabolic syndrome. Current hypertension reports, 20(2), 12.
Sianipar, D., & Lubis, R. (2025). Hubungan Aktivitas Fisik dan Kualitas Tidur dengan Kejadian Hipertensi pada Lansia di Wilayah Kerja Puskesmas Matiti Kecamatan Doloksanggul Tahun 2025: Penelitian. Jurnal Pengabdian Masyarakat dan Riset Pendidikan, 4(1), 3599-3605.
Sudarsono, E. K. R., Sasmita, J. F. A., Handyasto, A. B., Arissaputra, S. S., & Kuswantiningsih, N. (2017). Peningkatan pengetahuan tentang hipertensi guna perbaikan tekanan darah pada anak muda di Dusun Japanan, Margodadi, Sayegan, Sleman, Yogyakarta. Jurnal Pengabdian Kepada Masyarakat, 3(1), 26-38.
Sudayasa, I. P., Rahman, M. F., Eso, A., Jamaluddin, J., Parawansah, P., Alifariki, L. O., & Kholidha, A. N. (2020). Deteksi dini faktor risiko penyakit tidak menular pada masyarakat Desa Andepali Kecamatan Sampara Kabupaten Konawe. Journal of Community Engagement in Health, 3(1), 60-66.
Virdis, C., Sumby, K., Bartowsky, E., & Jiranek, V. (2021). Lactic acid bacteria in wine: Technological advances and evaluation of their functional role. Frontiers in microbiology, 11, 612118.
World Health Organization. (2018). Noncommunicable diseases: Risk factors and conditions. Diakses dari: https://www.who.int/data/gho/data/themes/topics/noncommunicable-diseases-risk-factors
Yarmaliza, Y., & Zakiyuddin, Z. (2019). Pencegahan dini terhadap penyakit tidak menular (PTM) melalui Germas. Jurnal Pengabdian Masyarakat Multidisiplin, 2(3), 93-100.
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