Digital interventions for adults with schizophrenia in clinical settings: A scoping review
DOI: https://doi.org/10.56922/mhc.v5i4.3639
Digital interventions Health technology Psychiatric nursing Schizophrenia Scoping review
Abstract
Background: Schizophrenia is a severe mental disorder that substantially affects quality of life and is associated with frequent relapse and poor treatment adherence. Although pharmacological treatment remains the cornerstone of schizophrenia management, digital technology-based interventions have increasingly been explored as complementary approaches to improve clinical and psychosocial outcomes.
Purpose: To identify and map the types of digital technology-based interventions used for the management of schizophrenia among adults in clinical settings and to describe the role of nurses in their implementation.
Method: A scoping review design following the Arksey and O'Malley framework, refined by the Joanna Briggs Institute, and reported according to the PRISMA-ScR guidelines. Literature searches were conducted in PubMed, Scopus, and ScienceDirect using the Population–Concept–Context framework. Primary studies published in English or Indonesian between 2019 and 2026 were included. From 13,637 identified records, 17 studies met the eligibility criteria and were analysed using descriptive and narrative synthesis.
Results: The included studies evaluated various digital interventions, including mobile applications, web-based platforms, virtual reality, telehealth, videoconference-delivered cognitive behavioural therapy, and other digital technologies. Several studies reported improvements in psychotic symptoms, cognitive functioning, treatment adherence, patient engagement, and quality of life. However, some interventions showed limited or no statistically significant improvements in specific clinical outcomes, indicating variability in effectiveness across intervention types and study settings. Across the included studies, nurses were consistently identified as facilitators of digital intervention implementation through patient education, digital literacy support, monitoring, and coordination of care.
Conclusion: Current evidence suggests that digital technology-based interventions may support schizophrenia management in clinical settings, although their reported effectiveness varies across intervention modalities and outcomes. Further high-quality studies are needed to determine the most effective approaches and to support the integration of digital interventions into routine psychiatric nursing practice.
Keywords: Digital interventions; Health technology; Psychiatric nursing; Schizophrenia; Scoping review.
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References
Anderson, J. K., Howarth, E., Vainre, M., Humphrey, A., Jones, P. B., & Ford, T. J. (2020). Advancing methodology for scoping reviews: Recommendations arising from a scoping literature review (SLR) to inform transformation of children and adolescent mental health services. BMC Medical Research Methodology, 20(1), 242.
Arnautovska, U., Trott, M., Vitangcol, K. J., Milton, A., Brown, E., Warren, N., & Siskind, D. (2025). Efficacy of user self-led and human-supported digital health interventions for people with schizophrenia: A systematic review and meta-analysis. Schizophrenia Bulletin, 51(5), 1402–1416.
Au-Yeung, C., Thai, H., Best, M., Bowie, C. R., Guimond, S., Lavigne, K. M., & Raucher-Chéné, D. (2025). iCogCA to promote cognitive health through digital group interventions for individuals living with a schizophrenia spectrum disorder: Protocol for a nonrandomized concurrent controlled trial. JMIR Research Protocols, 14(1), e63269.
Becker, M., Fischer, D. J., Kühn, S., & Gallinat, J. (2024). Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia. Translational Psychiatry, 14(1), 218.
Böge, K., Bergmann, N., Hahne, I., Emde, L., Cartner, S., Bell, I., & Thomas, N. (2025). Feasibility, acceptability and preliminary clinical outcomes of a brief coping-focused intervention for delusions blended with smartphone-based ecological momentary assessment and intervention in persons with schizophrenia spectrum disorders: A pilot single-arm trial. Internet Interventions, 39, 100804.
Bucci, S., Berry, N., Ainsworth, J., Berry, K., Edge, D., Eisner, E., & Haddock, G. (2024). Effects of Actissist, a digital health intervention for early psychosis: A randomized clinical trial. Psychiatry Research, 339, 116025.
Chong, H. Y., Teoh, S. L., Wu, D. B. C., Kotirum, S., Chiou, C. F., & Chaiyakunapruk, N. (2016). Global economic burden of schizophrenia: A systematic review. Neuropsychiatric Disease and Treatment, 12, 357–373.
El Abdellati, K., De Picker, L., & Morrens, M. (2020). Antipsychotic treatment failure: A systematic review on risk factors and interventions for treatment adherence in psychosis. Frontiers in Neuroscience, 14, 531763.
Freeman, D., Reeve, S., Robinson, A., Ehlers, A., Clark, D., Spanlang, B., & Slater, M. (2017). Virtual reality in the assessment, understanding, and treatment of mental health disorders. Psychological Medicine, 47(14), 2393–2400.
Ghaemi, S. N., Sverdlov, O., van Dam, J., Campellone, T., & Gerwien, R. (2022). A smartphone-based intervention as an adjunct to standard-of-care treatment for schizophrenia: Randomized controlled trial. JMIR Formative Research, 6(3), e29154.
Hua, Q., Wang, L., He, K., Sun, J., Xu, W., Zhang, L., & Ji, G. J. (2024). Repetitive transcranial magnetic stimulation for auditory verbal hallucinations in schizophrenia: A randomized clinical trial. JAMA Network Open, 7(11), e2444215.
Katsushima, M., Nakamura, H., Shiko, Y., Hanaoka, H., & Shimizu, E. (2025). Effectiveness of a videoconference-based cognitive behavioral therapy program for patients with schizophrenia: Pilot randomized controlled trial. JMIR Formative Research, 9, e59540.
Kidd, S. A., Feldcamp, L., Adler, A., Kaleis, L., Wang, W., Vichnevetski, K., & Voineskos, A. (2019). Feasibility and outcomes of a multi-function mobile health approach for the schizophrenia spectrum: App4Independence (A4i). PLoS ONE, 14(7), e0219491.
Kuhn, N. B. L., Maukel, L. M., & Tibubos, A. N. (2026). Effectiveness of eHealth interventions in long-term follow-up care for breast and gynecological cancer survivors: A systematic review. Supportive Care in Cancer, 34(6), 581.
Lal, S., Gleeson, J. F., D’Alfonso, S., Lepage, M., Joober, R., Lee, H., & Alvarez-Jimenez, M. (2024). Digital mental health intervention for schizophrenia spectrum and psychotic disorders: Protocol for a pragmatic feasibility study of Horyzons-Canada. Digital Health, 10, 20552076241282231.
Löchner, J., Carlbring, P., Schuller, B., Torous, J., & Sander, L. B. (2025). Digital interventions in mental health: An overview and future perspectives. Internet Interventions, 40, 100824.
Luther, L., Fischer, M. W., Johnson-Kwochka, A. V., Minor, K. S., Holden, R., Lapish, C. L., & Salyers, M. P. (2020). Mobile enhancement of motivation in schizophrenia: A pilot randomized controlled trial of a personalized text message intervention for motivation deficits. Journal of Consulting and Clinical Psychology, 88(10), 923–935.
Nahum, M., Lee, H., Fisher, M., Green, M. F., Hooker, C. I., Ventura, J., & Vinogradov, S. (2021). Online social cognition training in schizophrenia: A double-blind, randomized, controlled multi-site clinical trial. Schizophrenia Bulletin, 47(1), 108–117.
Raje, A., Rozatkar, A. R., Mehta, U. M., Shrivastava, R., Bondre, A., Ahmad, M. A., & Choudhary, S. (2025). Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study. Schizophrenia Research: Cognition, 40, 100347.
Ramdini, D. A., Koernia, L., & Antari, F. D. (2022). Gambaran lama rawat inap pada pasien skizofrenia dengan terapi kombinasi antipsikotik dan kombinasi antipsikotik dengan mood-stabilizer di Rumah Sakit Jiwa Provinsi Lampung. Jurnal Kedokteran Universitas Lampung, 6(2), 89–93.
Sohal, V. S. (2024). Neurobiology of schizophrenia. Current Opinion in Neurobiology, 84, 102820.
Thornicroft, G., Bakolis, I., Evans-Lacko, S., Gronholm, P. C., Henderson, C., Kohrt, B. A., & Sartorius, N. (2019). Key lessons learned from the INDIGO global network on mental health-related stigma and discrimination. World Psychiatry, 18(2), 229–230.
Torous, J., Bucci, S., Bell, I. H., Kessing, L. V., Faurholt-Jepsen, M., Whelan, P., & Firth, J. (2021). The growing field of digital psychiatry: Current evidence and the future of apps, social media, chatbots, and virtual reality. World Psychiatry, 20(3), 318–335.
Vass, E., Gerlinger, L., Egervári, L., Kilencz, T., Csukly, G., Hermán, L., & Simon, L. (2024). Exploring the acceptability and feasibility of a modified virtual reality-based AVATAR therapy in schizophrenia spectrum disorders: A case series report. Acta Psychologica, 250, 104520.
Wang, X., Kou, X., Meng, X., & Yu, J. (2022). Effects of a virtual reality serious game training program on the cognitive function of people diagnosed with schizophrenia: A randomized controlled trial. Frontiers in Psychiatry, 13, 952828.
Wind, T. R., Rijkeboer, M., Andersson, G., & Riper, H. (2020). The COVID-19 pandemic: The "black swan" for mental health care and a turning point for e-health. Internet Interventions, 20, 100317.
World Health Organization. (2022). Schizophrenia. World Health Organization. Retrieved From: https://www.who.int/news-room/fact-sheets/detail/schizophrenia
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