Common antidepressant side effect profiles and their management: A literature review
DOI: https://doi.org/10.56922/mhc.v4i5.2304
Antidepressants Adverse Effects Drug Safety Profile Management Literature Review
Abstract
Background: Antidepressant medications are widely used as a first-line treatment for depressive disorders and various other mental health conditions in both primary and hospital-based healthcare settings. Despite their proven efficacy in alleviating depressive symptoms, antidepressants are frequently associated with a range of adverse effects that may negatively impact patient adherence, treatment satisfaction, and long-term therapeutic outcomes. Understanding the safety profile of antidepressants is therefore essential for optimizing clinical management and improving treatment success.
Purpose: To review and synthesize current scientific evidence regarding the commonly encountered adverse effect profiles of antidepressant medications and the strategies used for their management in clinical practice.
Results: A literature review of studies published between 2020 and 2025 identified several frequently reported adverse effects associated with antidepressant use, including gastrointestinal disturbances, sleep disorders, sexual dysfunction, weight changes, and neurological symptoms such as headache and tremor. The adverse effect profiles varied across antidepressant classes, including selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, and atypical antidepressants. Management strategies commonly reported in the literature included dose adjustment, switching antidepressant agents or drug classes, the use of adjunctive therapies to alleviate specific adverse effects, and continuous patient education and monitoring to enhance treatment tolerability and adherence.
Conclusion: Antidepressant medications exhibit diverse adverse effect profiles that may compromise treatment effectiveness if not appropriately addressed. This literature review highlights the importance of recognizing commonly encountered adverse effects and implementing individualized, evidence-based management strategies to improve drug tolerability and patient adherence. An integrated and patient-centered approach is essential to optimize antidepressant therapy in clinical practice.
Keywords: Antidepressants; Adverse Effects; Drug Safety Profile; Management; Literature Review.
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References
American Psychiatric Association. (2020). Practice guideline for the treatment of patients with major depressive disorder . American Psychiatric Association. Am J Psychiatry, 167, 1.
Asqiya, A. I., Ningrum, W. A., Muthoharoh, A., & Permadi, Y. W. (2023). Pengaruh Penggunaan Obat Pada Pasien Depresi Terhadap Keberhasilan Obat Secara Subyektif Di RPSBM Kota Pekalongan. In Prosiding Seminar Nasional UNIMUS (Vol. 6).
Bahrick, A. S., & Harris, M. M. (2019). Sexual side effects of antidepressant medications: An informed consent accountability gap. Journal of Contemporary Psychotherapy, 39(2), 135-143.
Braund, T. A., Tillman, G., Palmer, D. M., Gordon, E., Rush, A. J., & Harris, A. W. (2021). Antidepressant side effects and their impact on treatment outcome in people with major depressive disorder: an iSPOT-D report. Translational psychiatry, 11(1), 417.
Chang, J. P. C., Zamparelli, A., Nettis, M., & Pariante, C. (2022). Antidepressant drugs: mechanisms of action and side effects. Encyclopedia of Behavioral Neuroscience, 1, V1-613.
Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., & Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. The Lancet, 391(10128), 1357-1366.
Davis, A. K., Barrett, F. S., May, D. G., Cosimano, M. P., Sepeda, N. D., Johnson, M. W., & Griffiths, R. R. (2021). Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial. JAMA psychiatry, 78(5), 481-489.
Edinoff, A. N., Akuly, H. A., Hanna, T. A., Ochoa, C. O., Patti, S. J., Ghaffar, Y. A., & Kaye, A. M. (2021). Selective serotonin reuptake inhibitors and adverse effects: a narrative review. Neurology international, 13(3), 387-401.
Gafoor, R., Booth, H. P., & Gulliford, M. C. (2018). Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study. Bmj, 361.
Hadawiyah, S., Lolok, N., & Hanafi, L. A. (2025). Analisis Drug Related Problems (DRPs) Obat Antidepresan Pada Pasien Depresi di Rumah Sakit Jiwa Kota Kendari Provinsi Sulawesi Tenggara. Jurnal Pharmacia Mandala Waluya, 4(6), 424-434.
Hamon, M., & Bourgoin, S. (2016). Pharmacological profile of antidepressants: a likely basis for their efficacy and side effects?. European Neuropsychopharmacology, 16, S625-S632.
Healy, D., Le Noury, J., & Mangin, D. (2018). Enduring sexual dysfunction after treatment with antidepressants, 5 α-reductase inhibitors and isotretinoin: 300 cases. International Journal of Risk & Safety in Medicine, 29(3-4), 125-134.
Jolstedt, M. (2019). Internet-delivered cognitive behaviour therapy for paediatric anxiety disorders in clinical settings: increasing access to evidence-based treatments. Karolinska Institutet (Sweden).
Montejo, A. L., Montejo, L., & Navarro-Cremades, F. (2025). Sexual side-effects of antidepressant and antipsychotic drugs. Current opinion in psychiatry, 28(6), 418-423.
Oliva, V., Lippi, M., Paci, R., Del Fabro, L., Delvecchio, G., Brambilla, P., & Serretti, A. (2021). Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: a systematic review and meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 109, 110266.
Pannu, A., & Goyal, R. K. (2025). From evidence to practice: A comprehensive analysis of side effects in synthetic anti-depressant therapy. Current Drug Safety, 20(2), 120-147.
Wang, S. M., Han, C., Bahk, W. M., Lee, S. J., Patkar, A. A., Masand, P. S., & Pae, C. U. (2018). Addressing the side effects of contemporary antidepressant drugs: a comprehensive review. Chonnam medical journal, 54(2), 101-112.
Zhou, J., Sun, H., Wang, Z., Cong, W., Zeng, M., Zhou, W., & Fan, J. (2023). Guidelines for the diagnosis and treatment of primary liver cancer (2022 edition). Liver cancer, 12(5), 405-444.
Zhou, J., Sun, H., Wang, Z., Cong, W., Zeng, M., Zhou, W., & Fan, J. (2025). China liver cancer guidelines for the diagnosis and treatment of hepatocellular carcinoma (2024 edition). Liver Cancer, 14(6), 779-835.
Zolghadriha, A., Anjomshoaa, A., Jamshidi, M. R., & Taherkhani, F. (2024). Rapid and sustained antidepressant effects of intravenous ketamine in treatment-resistant major depressive disorder and suicidal ideation: a randomized clinical trial. BMC psychiatry, 24(1), 341.
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