Mucinous borderline tumor ovarium pada wanita pascamenopause dengan massa abdomen giant: Laporan kasus
Case Report
DOI: https://doi.org/10.56922/quilt.v6i8.3763
Adnexal Mass Borderline Ovarian Tumor Case Report; Ovarian Neoplasm Mucinous Borderline Ovarian Tumor.
Abstract
Background: Mucinous borderline ovarian tumor (MBOT) is a subtype of borderline ovarian tumor (BOT) characterized by atypical epithelial proliferation without destructive stromal invasion. This tumor exhibits a biologic behavior intermediate between benign neoplasms and invasive ovarian carcinomas and often exhibits slow growth, reaching a large size before diagnosis. Preoperative diagnosis is often challenging because its clinical and radiological features can mimic both benign and malignant ovarian tumors.
Purpose: To describe the clinical, imaging, intraoperative, and histopathological findings of a large mucinous borderline ovarian tumor in a postmenopausal woman and to highlight the importance of histopathological examination in establishing the definitive diagnosis.
Case Report: A 51-year-old postmenopausal woman presented with abdominal enlargement that had been increasing for six months. Ultrasonography revealed a lobulated cystic ovarian neoplasm measuring 18 × 20 cm and 14 × 13 cm. Routine laboratory tests were generally normal. The patient underwent exploratory laparotomy and removal of the ovarian mass. Intraoperative findings revealed a right cystic ovarian neoplasm with adhesions to the omentum and bowel. Histopathology revealed a multilocular cyst wall lined with mucinous columnar epithelium with areas of epithelial stratification, hyperchromatic nuclei, and micropapillae formation without evidence of stromal invasion, confirming the diagnosis of mucinous borderline ovarian tumor.
Results: Mucinous borderline ovarian tumor is a relatively rare ovarian epithelial neoplasm often presenting as a large, multilocular mass. Ultrasonography plays a crucial role in the initial evaluation, but definitive diagnosis relies on histopathology. The primary treatment is complete surgical resection, especially in postmenopausal patients who are at higher risk of malignancy.
Conclusion: Mucinous borderline ovarian tumor should be considered as a differential diagnosis in postmenopausal women with a large abdominal mass. Correlation between clinical, imaging, intraoperative, and histopathological findings is crucial for establishing the diagnosis and determining appropriate management.
Keywords: Adnexal Mass; Borderline Ovarian Tumor; Case Report; Ovarian Neoplasm; Mucinous Borderline Ovarian Tumor.
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References
Arora, T., Mullangi, S., Vadakekut, E. S., & Lekkala, M. R. (2026). Epithelial ovarian cancer. In StatPearls. StatPearls Publishing.
Fischerova, D., Zikan, M., Dundr, P., & Cibula, D. (2012). Diagnosis, treatment, and follow-up of borderline ovarian tumors. The Oncologist, 17(12), 1515–1533.
González-Martín, A., Harter, P., Leary, A., Lorusso, D., Miller, R. E., Pothuri, B., Ray-Coquard, I., Tan, D. S. P., Bellet, E., Oaknin, A., & Ledermann, J. A. (2023). Newly diagnosed and relapsed epithelial ovarian cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of Oncology, 34(10), 833–848.
Hendrianto, H., Ongko, N. X., Nadapdap, F. M., Tarigan, S. B., Arhamni, A., Jansen, J., Sopacua, E., & Artiani, L. (2023). Tinjauan pustaka mengenai tumor ovarium. Buletin Kedokteran & Kesehatan Prima, 2(1), 8–10.
Liu, J., Berchuck, A., Backes, F. J., Cohen, J., Grisham, R., Leath, C. A., Martin, L., Matei, D., Miller, D. S., Robertson, S., Barroilhet, L., Uppal, S., Wahner Hendrickson, A., Gershenson, D. M., Gray, H. J., Hakam, A., Jain, A., Konecny, G. E., Moroney, J., ... Armstrong, D. K. (2024). NCCN Guidelines® Insights: Ovarian Cancer/Fallopian Tube Cancer/Primary Peritoneal Cancer, Version 3.2024. Journal of the National Comprehensive Cancer Network, 22(8), 512–519.
Massobrio, R., Mariani, L. L., Conti, D., De Grandis, T., Buonomo, F., Badellino, E., Novara, L., Bounous, V. E., Perotto, S., Mancarella, M., Ferrero, A., Biglia, N., & Fuso, L. (2024). Ultrasonographic diagnosis of adnexal masses: Interobserver agreement in the interpretation of videos, using IOTA terminology. Archives of Gynecology and Obstetrics, 309, 211–218.
Milan, J., El Hajj, C., Jradi, A., & Azar, A. (2025). Huge mucinous ovarian borderline tumor: A case report. Journal of Surgical Case Reports, 2025(12), rjaf1000.
Reid, B. M., Permuth, J. B., & Sellers, T. A. (2017). Epidemiology of ovarian cancer: A review. Cancer Biology & Medicine, 14(1), 9–32.
Sadlecki, P., Dejewska, K., Domieracka, P., & Walentowicz-Sadlecka, M. (2025). Giant mucinous borderline ovarian tumor: Challenges of diagnosis and treatment. Archives of Gynecology and Obstetrics, 311(4), 1205–1207.
Szymańska-Dubowik, A., Śniadecki, M., Bianek-Bodzak, A., Liro, M., & Szurowska, E. (2016). Mucinous borderline ovarian tumor: A case report with diagnostic insights on ultrasound findings. Journal of Ultrasonography, 16(67), 411–416.
Timmerman, D., Testa, A. C., Bourne, T., Ameye, L., Jurkovic, D., Van Holsbeke, C., Paladini, D., Van Calster, B., Vergote, I., Van Huffel, S., & Valentin, L. (2008). Simple ultrasound-based rules for the diagnosis of ovarian cancer. Ultrasound in Obstetrics & Gynecology, 31(6), 681–690.
Troupi, M., Koliopoulos, S., Shihada, A., Samolis, A., Chrysikos, D., & Troupis, T. (2025). Large mucinous borderline ovarian tumor in an asymptomatic woman: A case report. Cureus, 17(9), e91805.
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