Dampak determinan sosial dan lingkungan terhadap korelasi diabetes mellitus dan positivitas tuberkulosis
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DOI: https://doi.org/10.56922/quilt.v6i6.3601
2 Hours Postprandial Glucose BTA Positivity Diabetes Mellitus
Abstract
Background: Tuberculosis and diabetes mellitus constitute a dual epidemic with significant public health implications. Social and environmental determinants—such as overcrowded housing, poor ventilation, and a history of tuberculosis exposure within the household—play a role in reinforcing the correlation between diabetes mellitus and tuberculosis positivity.
Purpose: To fill this gap through a comprehensive analysis of the relationship between 2-hour postprandial glucose levels, social determinants, and environmental determinants on TB positivity in DM patients.
Methods: A retrospective case-control observational study. Correlation analysis of 2-hour postprandial glucose levels with acid-fast bacilli scores was performed using Spearman’s and Kruskal-Wallis tests. Logistic regression analysis was used to identify independent determinants.
Results: The mean 2-hour postprandial glucose level in the case group was 178.28 ± 13.48 mg/dL. The Spearman correlation between 2-hour postprandial glucose levels and acid-fast bacilli scores was positive and significant. The highest acid-fast bacilli positivity was observed in the moderate hyperglycaemia group. The Kruskal-Wallis test revealed significant differences between categories. Glucose levels ≥181 mg/dL, a history of tuberculosis contact within the household, high housing density and poor ventilation were identified as exposure variables for diabetes mellitus-tuberculosis comorbidity.
Conclusion: There is a positive and significant correlation between 2-hour postprandial glucose levels and acid-fast bacilli positivity scores in patients with diabetes mellitus and tuberculosis. Environmental determinants such as high housing density, poor ventilation, and household contact with tuberculosis significantly reinforce the correlation between diabetes mellitus and tuberculosis positivity.
Keywords: 2 Hours Postprandial Glucose; BTA Positivity; Diabetes Mellitus.
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