Silent threat in early pregnancy: A case of spontaneous heterotopic pregnancy with tubal rupture

DOI: https://doi.org/10.33024/minh.v8i7.968

Authors

  • Nizan Dani Oktama Program Studi Obstetrik dan Ginekologi, Universitas Riau
  • Edy Fakhrizal Program Studi Obstetrik dan Ginekologi, Universitas Riau

Emergency Laparotomy Heterotopic Pregnancy Spontaneous Conception Tubal Rupture

Abstract

Background: Heterotopic pregnancy (HP) is a rare but potentially life-threatening condition characterized by the coexistence of intrauterine and extrauterine pregnancies. While its incidence in natural conception is estimated at 1 in 30,000 cases, the risk increases considerably with the use of assisted reproductive technologies. Because its symptoms often mimic those of ectopic pregnancy, HP remains a diagnostic challenge, particularly in patients without recognized risk factors.

Purpose: To highlight the silent yet serious threat of spontaneous heterotopic pregnancy in early gestation, illustrated by a case of tubal rupture in a natural conception.

Method: A descriptive case report of a 43-year-old multigravida woman who presented at 7 weeks of gestation with sudden lower abdominal pain and clinical features of intra-abdominal hemorrhage. Diagnostic evaluation included ultrasonography and laboratory investigations, followed by an emergency laparotomy.

Results: Ultrasound imaging revealed two intrauterine gestational sacs along with free fluid in the pouch of Douglas. Laboratory tests indicated anemia (hemoglobin 8.1 g/dL) and marked leukocytosis. Emergency laparotomy confirmed a ruptured right fallopian tube with massive intraperitoneal bleeding. The patient underwent right salpingectomy, left tubectomy, and intrauterine curettage at her request. Her postoperative recovery was uneventful, and she was discharged in good condition after two days.

Conclusion: This case underscores the diagnostic difficulty of heterotopic pregnancy in spontaneous conceptions. The presence of an intrauterine pregnancy may create false reassurance, masking a concurrent ectopic gestation. Clinicians should consider HP in the differential diagnosis of any reproductive-aged woman with abdominal pain, regardless of conception method, to prevent life-threatening maternal complications.

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References

Adewole, A., Asaolu, O. A., & Akintobi, A. O. (2022). Laparoscopic Tubal Surgery and Laparoscopic Management of Ectopic Pregnancy. Gynaecological Endoscopic Surgery, 159–184.

Brincat, M., Bryant-Smith, A., & Holland, T. K. (2019). The diagnosis and management of interstitial ectopic pregnancies: a review. Gynecol Surgery, 16(2).

Byamukama, A., Bibangambah, P., Rwebazibwa, J., Acan, M., & Sebikali, M. J. (2023). Advanced abdominal ectopic pregnancy and the role of antenatal ultrasound scan in its diagnosis and management. Radiology case reports, 18(12), 4409–4413.

Chaves, L. T., Maia, R., Borges Peixoto, A., Araujo, E., & Elito, J. (2024). Tubal ectopic pregnancy: comparative management between pre and Covid-19 pandemic periods. Revista brasileira de ginecologia e obstetricia: revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 46, e-rbgo64.

Chukus, A., Tirada, N., Restrepo, R., & Reddy, N. I. (2015). Uncommon Implantation Sites of Ectopic Pregnancy: Thinking beyond the Complex Adnexal Mass. Radiographics: a review publication of the Radiological Society of North America, Inc, 35(3), 946–959

Eisner, S. M., Ebert, A. D., & David, M. (2020). Rare Ectopic Pregnancies - A Literature Review for the Period 2007 - 2019 on Locations Outside the Uterus and Fallopian Tubes. Geburtshilfe und Frauenheilkunde, 80(7), 686–701.

El Hajjar, C., Aouad, R., Hamouche, H., Chamsy, D. J., & Atallah, D. (2024). Advanced abdominal ectopic pregnancy complicated by pelvic presentation: A case report. SAGE Open Medical Case Reports, 12, 2050313X241288432.

Fessehaye, A., Gashawbeza, B., Daba, M., Arusi, M., & Terefe, T. (2021). Abdominal ectopic pregnancy complicated with a large bowel injury: a case report. Journal of medical case reports, 15(1), 127.

Geffen, E. M., Slywotzky, C., & Bennett, G. (2017). Pitfalls and tips in the diagnosis of ectopic pregnancy. Abdominal radiology (New York), 42(5), 1524–1542.

Giacometti, C., Bellan, E., Ambrosi, A., Dei Tos, A. P., Cassaro, M., & Ludwig, K. (2021). "While there is p57, there is hope." The past and the present of diagnosis in first trimester abortions: Diagnostic dilemmas and algorithmic approaches. A review. Placenta, 116, 31–37.

Hamam, Y. A., Zimmo, M., Alqeeq, B. F., Hijazi, Y. M., Hamam, M., & Al-Hajjar, M. (2024). Advanced Secondary Abdominal Ectopic Pregnancy with Live Fetus at 26-Weeks’ Gestation Following In vitro Fertilization: A Case Report. SAGE Open Medical Case Reports, 12.

Huang, K., Song, L., Wang, L., Gao, Z., Meng, Y., & Zhu, J. (2014). Advanced abdominal pregnancy: An increasingly recognized challenge. Obstetrics and Gynecology International, 2014, 582852.

Kumar, P., & Malhotra, N. (2017). Principle of Gynaecology: Ectopic pregnancy (7th ed.). Brothers Medical Publishers.

Mj, G., & Rajan, R. (2008). Heterotopic pregnancy in natural conception. Journal of human reproductive sciences, 1(1), 37–38.

Okda, H. G., Hamed, N., Aziz, S. A., & Khalifa, I. E. (2021). Advanced abdominal pregnancy at full term with live fetus invading colon mesentery. Obstetrics and Gynaecology Cases Reviews, 8, 216.

OuYang, Z., Wei, S., Wu, J., Wan, Z., Zhang, M., & Zhong, B. (2021). Retroperitoneal ectopic pregnancy: A literature review of reported cases. European journal of obstetrics, gynecology, and reproductive biology, 259, 113–118.

Payne, S., Duge, J., & Bradbury, W. (1971). Ectopic pregnancy concomitant with twin intrauterine pregnancy. A case reports. Obstetrics and gynecology, 38(6), 905–906.

Pekar-Zlotin, M., Rabinovich, I., Goldrat, I., Vaknin, Z., Gidoni, Y., Zur-Naaman, H., Maymon, R., & Smorgick, N. (2021). Ovarian Dermoid Cysts Associated with Paraneoplastic Syndrome N-methyl-D-aspartic Acid Receptor Antibodies Encephalitis. Journal of minimally invasive gynecology, 28(6), 1190–1193.

Tegene, D., Nesha, S., Gizaw, B., & Befikadu, T. (2022). Laparotomy for Advanced Abdominal Ectopic Pregnancy. Case reports in obstetrics and gynecology, 2022, 3177810.

Wenjing, L., & Haibo, L. (2022). Therapeutic effect of laparoscopic salpingotomy vs. salpingectomy on patients with ectopic pregnancy: A systematic review and meta-analysis. Frontiers in Surgery, 9, 997490.

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Published

2025-09-29

How to Cite

Silent threat in early pregnancy: A case of spontaneous heterotopic pregnancy with tubal rupture. (2025). MIN, 8(7), 917-922. https://doi.org/10.33024/minh.v8i7.968