Effect of red betel (Piper crocatum Ruiz and Pav) leaves extract on blood glucose levels and ankle brachial pressure index (ABPI) among patients with type 2 diabetes mellitus
DOI: https://doi.org/10.33024/minh.v8i2.859
Betel Leaf Extract Blood Sugar Glycemic Control Type 2 Diabetes Mellitus
Abstract
Background: Hyperglycemia often occurs in DM patients even though they have received pharmacological therapy, thus encouraging people to consume herbal medicines. The dosage of herbal therapy consumed by the community is not appropriate, only the dosage of community assumptions, resulting in negative impacts. Chronic hyperglycemia causes worsening of the Ankle Brachial Pressure Index (ABPI) score. Giving red betel extract with the right dose can be a solution, because red betel extract contains flavonoids that can inhibit y-amylase and y-glucosidase so that the body can control blood sugar levels and improve ABPI scores.
Purpose: To determine effectiveness of red betel extract on fasting blood sugar levels and ABPI.
Method: A quasy experiment approach, specially focusing on pretest and posttest group. The study took place from October-November 2024, in Padangsari and Srondol Health Centers, Semarang. The independent variable was red betel leaf extractthe dependent variables is fasting blood sugar levels and ABPI. Using purposive sampling and Lemeshow formula, 70 respondents were selected which were divided into 2 groups, who met specific inclusion and exclusion criteria. Analysis proceeded with a univariate test to determine the frequency distribution of respondent’s characteristics, followed by bivariate analysis using man whitney test.
Results: Red betel leaf extract significantly reduced blood sugar levels in patients with type 2 diabetes mellitus with an intervention value of 112.83 ± 15.227 compared to control of 191.46 ± 72277 with a large Cohen's d effect of 0.87 and increased the value of the Ankle Brachial Pressure Index or ABPI in the intervention group by 0.855 ± 0.045 compared to control by 0.674 ± 0.094 with a large d effect of 1.22 These findings suggest that red beet extract has potential as an adjuvant therapy in glycemic control and improvement of peripheral circulation.
Conclusion: Betel leaf extract has been shown to be effective in reducing fasting blood sugar levels and improving Ankle Brachial Pressure Index (ABPI) scores in patients with type II diabetes mellitus.
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Argyropoulou, D., Nomikos, T., Terzis, G., Tataki, S., Geladas, N. D., & Paschalis, V. (2025). The Effects Of Dietary Protein On Physical Performance And Body Composition In Middle Age And Older People Having Type II Diabetes Mellitus: A Randomized Pilot Study. European Journal Of Nutrition, 64(1), 63.
Casey, S., Lanting, S., Oldmeadow, C., & Chuter, V. (2019). The Reliability Of The Ankle Brachial Index: A Systematic Review. Journal Of Foot And Ankle Research, 12, 1-10.
Dar, M. I., Gulya, A., Abass, S., Dev, K., Parveen, R., Ahmad, S., & Qureshi, M. I. (2024). Hallmarks Of Diabetes Mellitus And Insights Into The Therapeutic Potential Of Synergy-Based Combinations Of Phytochemicals In Reducing Oxidative Stress-Induced Diabetic Complications. Natural Product Research, 1-15.
Dias, M. C., Pinto, D. C., & Silva, A. M. (2021). Plant Flavonoids: Chemical Characteristics And Biological Activity. Molecules, 26(17), 5377.
Hartono, H., & Ediyono, S. (2024). Hubungan Tingkat Pendidikan, Lama Menderita Sakit Dengan Tingkat Pengetahuan 5 Pilar Penatalaksanaan Diabetes Mellitus Di Wilayah Kerja Puskesmas Sungai Durian Kabupaten KBU Raya Kalimantan Barat. The Shine Cahaya Dunia S-1 Keperawatan, 9(01).
Ingrosso, D. M. F., Primavera, M., Samvelyan, S., Tagi, V. M., & Chiarelli, F. (2023). Stress And Diabetes Mellitus: Pathogenetic Mechanisms And Clinical Outcome. Hormone Research In Paediatrics, 96(1), 34-43.
Lariwu, C. K., Sarayar, C. P., Pondaag, L., Merentek, G., & Lontaan, E. M. (2024). Indeks Masa Tubuh, Riwayat Keluarga Dan Kebiasaan Konsumsi Gula: Faktor Dominan Penyebab Diabetes Melitus Tipe 2 Pada Lanjut Usia Di Kota Tomohon. AKSARA: Jurnal Ilmu Pendidikan Nonformal, 10(1), 379-386.
Li, X., Zou, J., Lin, A., Chi, J., Hao, H., Chen, H., & Liu, Z. (2024). Oxidative Stress, Endothelial Dysfunction, And N-Acetylcysteine In Type 2 Diabetes Mellitus. Antioxidants & Redox Signaling, 40(16-18), 968-989.
Mallik, S., Paria, B., Firdous, S. M., Ghazzawy, H. S., Alqahtani, N. K., He, Y., & Gouda, M. M. (2024). The Positive Implication Of Natural Antioxidants On Oxidative Stress-Mediated Diabetes Mellitus Complications. Journal Of Genetic Engineering And Biotechnology, 22(4), 100424.
Meyyazhagan, P., Kanagaraj, T., & Annamalai, N. (2025). A Cross-Sectional Study On Effect Of Glycaemic Status And Duration Of Type II Diabetes Mellitus On The Pulmonary Function. Journal Of Basic And Clinical Physiology And Pharmacology, (0).
Mudassar, S., Lakho, M. A., Anwar, R., Rehman, M. A. U., Zakir, H., & Joher, I. (2025). Ankle-Brachial Pressure Index Correlates With Abdominal Volume Index In Normal-Weight Type 2 Diabetes Mellitus Patients: Role Of ABPI And ABV In T2DM. Pakistan Journal Of Health Sciences, 337-342.
Parekh, R. A., Athavale, V., & Kelshikar, S. (2024). The Value Of Pressure Indexes In Predicting The Outcome Of Diabetic Foot Ulcers As A Guide To Further Management. Cureus, 16(9).
Prayitno, S. A., & Murtini, E. S. (2018). Karakteristik (Total Flavonoid, Total Fenol, Aktivitas Antioksidan) Ekstrak Serbuk Daun Sirih Merah (Piper Crocatum Ruiz & Pav.). Food Science And Technology Journal (Foodscitech), 1(2), 26-34.
Rais, N., Ved, A., Ahmad, R., & Parveen, A. (2024). Oxidative Stress And Diabetes Mellitus: Unravelling The Intricate Connection: A Comprehensive Review. Journal Of Pharmaceutical Research International, 36(1), 13-30.
Rizqi, P. M. S., Dewi, S., Barokah, W., & Susanti, N. (2024). Hubungan Usia, Jenis Kelamin Terhadap Pola Makan Dan Risiko Diabetes Melitus Di Desa Air Hitam. Jurnal Kesehatan Tambusai, 5(3), 7484-7491.
Rohmatulloh, V. R., Riskiyah, R., Pardjianto, B., & Kinasih, L. S. (2024). Hubungan Usia Dan Jenis Kelamin Terhadap Angka Kejadian Diabetes Melitus Tipe 2 Berdasarkan 4 Kriteria Diagnosis Di Poliklinik Penyakit Dalam RSUD Karsa Husada Kota Batu. PREPOTIF: Jurnal Kesehatan Masyarakat, 8(1), 2528-2543.
Roshan, R., Chaudhary, N., Chouhan, U., Huda, F., & Basu, S. (2024). Correlation Of Ankle–Wrist Pressure Index With Ankle–Brachial Pressure Index To Assess Lower Limb Perfusion In Diabetic Foot Ulcer: A Pilot Study. Journal Of Wound Care, 33(7), 519-525.
Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., & IDF Diabetes Atlas Committee. (2019). Global And Regional Diabetes Prevalence Estimates For 2019 And Projections For 2030 And 2045: Results From The International Diabetes Federation Diabetes Atlas. Diabetes Research And Clinical Practice, 157, 107843.
Sari, E. K. (2022). Pengaruh Ekstrak Daun Sirih Merah Terhadap Gula Darah Sewaktu Penderita Diabetes Melitus Di UPT Puskesmas Branti Raya Lampung Selatan. Jurnal Ilmu Keperawatan Indonesia, 3(2), 97-103.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health And Treatment Of Diabetes Mellitus. International Journal Of Health Sciences, 5(1), 572192.
Wahyuni, S., Hasanah, F. H., & Lusiana, A. E. (2023). Kolerasi Glukosa Darah Dengan Hs-Crp Pada Pasien Diabetes Melitus Tipe 2. Jurnal Insan Cendekia, 10(2), 132-136.
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