The role of low-level laser therapy as a complementary approach in promoting wound healing among patients with diabetic foot ulcers: A systematic review

DOI: https://doi.org/10.33024/minh.v8i2.835

Authors

  • Rosana Nurwulandari Fakultas Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman
  • Yunita Sari Fakultas Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman

Diabetic Foot Ulcers Low-level Laser Therapy Pain Levels Wound Healing

Abstract

Background: A common and complicated side effect of diabetes is diabetic foot ulcers (DFUs), which frequently lead to chronic wounds that are challenging to heal. Another technique that has gained interest is low-level laser therapy (LLLT), which speeds up the healing of diabetic foot ulcers. The purpose of this systematic review is to evaluate how well LLLT aids in the healing of diabetic foot ulcers that are chronic.

Purpose: To assess the effects of low-level laser therapy on the healing of diabetic foot ulcers, particularly with regard to ulcer size reduction, pain relief, and overall wound healing.

Method: A comprehensive search for English-language full-text studies published between 2015 and 2024 was conducted across a number of databases, including PubMed, ScienceDirect, and Google Scholar. Randomized controlled trials that assessed the impact of LLLT on diabetic foot ulcers are required for inclusion. Measurements of wound size, ulcer healing progress, and pain reduction were used to analyze the results.

Results: The analysis includes seven studies that consistently showed benefits from using LLLT. Significant decreases in ulcer size, better tissue repair, and when comparing the treated groups to the control groups, pain relief was seen. Although different laser parameters, such as wavelengths and dosages, were reported in the research, all of them shown positive outcomes in terms of speeding up wound healing and lowering pain levels related to diabetic foot ulcers.

Conclusion: Low-level laser therapy is a useful supplementary technique for promoting the healing of diabetic foot ulcers. Patients with chronic diabetic foot ulcers benefit from LLLT by experiencing less pain, faster wound healing, and an overall higher quality of life. To ascertain the optimal laser parameters and assess the long-term efficacy of LLLT in the management of diabetic wounds, more extensive research is necessary.

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References

Abesi, F., & Derikvand, N. (2023). Efficacy of low-level laser therapy in wound healing and pain reduction after gingivectomy: a systematic review and meta-analysis. Journal of lasers in medical sciences, 14, e17.

Alpiah, D. N., & Alfiyani, F. N. (2023). Efektivitas low-level laser therapy Terhadap Penyembuhan Luka Ulkus Kaki Diabetik: Literature Review: The Effectiveness of low-level laser therapy on Diabetic Foot Ulcus: A Literature Review. Binawan Student Journal, 5(3), 44-53.

Andrade, F. D. S. D. S. D., Clark, R. M. D. O., & Ferreira, M. L. (2014). Efeitos da laserterapia de baixa potência na cicatrização de feridas cutâneas. Revista do Colégio Brasileiro de Cirurgiões, 41, 129-133.

Argenis, G., Aguilar, A., & Najar, K. (2022). low-level laser therapy at the Healing Process of Grade I And II Ulcers in Patients with Diabetic Foot. European Scientific Journal, ESJ, 18, 17-78.

Bashiri, H. (2013). Evaluation of low-level laser therapy in reducing diabetic polyneuropathy related pain and sensorimotor disorders. Acta Medica Iranica, 543-547.

Beckmann, K. H., Meyer-Hamme, G., & Schröder, S. (2014). Low level laser therapy for the treatment of diabetic foot ulcers: a critical survey. Evidence‐Based Complementary and Alternative Medicine, 2014(1), 626127.

Cardoso, V. S., Dos Santos, C. M., da Rocha, R. B., & Hazime, F. A. (2021). Dose-response and efficacy of low-level laser therapy on diabetic foot ulcers healing: Protocol of a randomized controlled trial. Contemporary Clinical Trials, 110, 106561.

Carvalho, A. F. M. D., Feitosa, M. C. P., Coelho, N. P. M. D. F., Rebêlo, V. C. N., Castro, J. G. D., Sousa, P. R. G. D., & Arisawa, E. A. L. S. (2016). Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers. Revista da Escola de Enfermagem da USP, 50(04), 0628-0634.

Elmer, C. J. (2019). Is low-level laser therapy (LLLT) Effective in Reducing Pain and Ulcer Size in Diabetic Patients with Foot Ulcers?

Feitosa, M. C. P., Carvalho, A. F. M. D., Feitosa, V. C., Coelho, I. M., Oliveira, R. A. D., & Arisawa, E. Â. L. (2015). Effects of the low-level laser therapy (LLLT) in the process of healing diabetic foot ulcers. Acta cirurgica brasileira, 30(12), 852-857.

Hendra, M., Nugraha, S., Wahyuni, N., Ayu, P., & Saraswati, S. (2019). Neuromucular Facilitation pada Ulkus Diabetikum the Effectiveness of Low Power Laser Therapy and Proprioceptive Neuromuscular Facilition on Grade 2. Diabetic Foot Ulcers, 43-50.

Hopkins, J. T., McLoda, T. A., Seegmiller, J. G., & Baxter, G. D. (2004). Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. Journal of athletic training, 39(3), 223.

Huang, J., Chen, J., Xiong, S., Huang, J., & Liu, Z. (2021). The effect of low‐level laser therapy on diabetic foot ulcers: A meta‐analysis of randomised controlled trials. International wound journal, 18(6), 763-776.

Júnior, R. A. M., Vieira, B. J., Andrade, L. C. F. D., & Aarestrup, F. M. (2007). Effects of low-level laser therapy on the progress of wound healing in humans: the contribution of in vitro and in vivo experimental studies. Jornal Vascular Brasileiro, 6, 257-265.

Kajagar, B. M., Godhi, A. S., Pandit, A., & Khatri, S. (2012). Efficacy of low-level laser therapy on wound healing in patients with chronic diabetic foot ulcers—a randomised control trial. Indian Journal of Surgery, 74(5), 359-363.

Lin, L., Li, J., Lin, J., Tang, S., & Li, Y. (2021). Effectiveness and safety of low-level laser therapy in diabetic peripheral neuropathy: a protocol for a systematic review and meta-analysis. Systematic Reviews, 10, 1-7.

Lucas, C., Stanborough, R. W., Freeman, C. L., & De Haan, R. J. (2000). Efficacy of low-level laser therapy on wound healing in human subjects: a systematic review. Lasers in Medical Science, 15, 84-93.

Mokmeli, S., Daemi, M., Ayatollahzadeh, S. Z., Ayatollahzadeh, S. F., & Hajizadeh, M. (2010). Evaluating the efficiency of low-level laser therapy (LLLT) in combination with intravenous laser therapy (IVL) on diabetic foot ulcer, added to conventional therapy.

Priyadarshini, L. M. J., Babu, K. E. P., & Thariq, I. A. (2018). Effect of low-level laser therapy on diabetic foot ulcers: a randomized control trial. Int. Surg. J, 5, 1008-1015.

Raja, J. M., Maturana, M. A., Kayali, S., Khouzam, A., & Efeovbokhan, N. (2023). Diabetic foot ulcer: a comprehensive review of pathophysiology and management modalities. World journal of clinical cases, 11(8), 1684.

Rashidi, S., Yadollahpour, A., & Mirzaiyan, M. (2015). Low level laser therapy for the treatment of chronic wound: Clinical considerations. Biomedical and Pharmacology Journal, 8(2), 1121-1127.

Santos, J. D. A. F., Campelo, M. B. D., de Oliveira, R. A., Nicolau, R. A., Rezende, V. E. A., & Arisawa, E. Â. L. (2018). Effects of low-power light therapy on the tissue repair process of chronic wounds in diabetic feet. Photomedicine and laser surgery, 36(6), 298-304.

Seyyedi, S. A., Taram, S., Heydari, M., & Valizadeh, R. (2022). Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis. Exploration of Medicine, 3(5), 451-460.

Srilestari, A., Nareswari, I., Simadibrata, C., & Tarigan, T. J. (2017). Effectiveness of combined laser-puncture and conventional wound care to accelerate diabetic foot ulcer healing. Medical Journal of Indonesia, 26(1), 26-34.

Torkaman, G., Hoseini-Sanati, M., Hedayati, M., Mofid, M., & Iranparvar Alamdari, M. (2024). Effects of photobiomodulation therapy on the expression of hypoxic inducible factor, vascular endothelial growth factor, and its specific receptor: a randomized control trial in patients with diabetic foot ulcer. Photobiomodulation, Photomedicine, and Laser Surgery, 42(4), 275-284.

Wadee, A. N., Fahmy, S. M., & Bahey El-Deen, H. A. (2021). low-level laser therapy (photobiomodulation) versus hyperbaric oxygen therapy on healing of chronic diabetic foot ulcers: a controlled randomized trial. Physical Therapy Reviews, 26(1), 73-80.

Wang, J. Y., Huang, Z. Q., Deng, H. P., Zhao, L., Deng, H. Y., Liu, J. P., & Cheng, K. (2022). Low level light therapy/photobiomodulation for diabetic peripheral neuropathy: protocol of a systematic review and meta-analysis. BMJ open, 12(9), e059476.

Wang, X., Yuan, C. X., Xu, B., & Yu, Z. (2022). Diabetic foot ulcers: Classification, risk factors and management. World journal of diabetes, 13(12), 1049.

Wijaya, L., Budiyanto, A., & Astuti, I. (2019). Pathogenesis, evaluation, and recent management of diabetic foot ulcer. Journal of the Medical Sciences (Berkala Ilmu Kedokteran), 51(1), 82-97.

Yang, L., Rong, G. C., & Wu, Q. N. (2022). Diabetic foot ulcer: challenges and future. World journal of diabetes, 13(12), 1014.

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Published

2025-04-21

How to Cite

The role of low-level laser therapy as a complementary approach in promoting wound healing among patients with diabetic foot ulcers: A systematic review. (2025). MIN, 8(2), 182-192. https://doi.org/10.33024/minh.v8i2.835