Vasoactive-inotropic score for prediction of critical patient mortality: A systematic review

DOI: https://doi.org/10.33024/minh.v8i2.481

Authors

  • Umarmono Umarmono Universitas Jenderal Soedirman
  • Iwan Purnawan Universitas Jenderal Soedirman

Patient Mortality Prediction of Critical Vasoactive-Inotropic Score (VIS)

Abstract

Background: A medical emergency is a clinical situation that requires immediate and planned treatment to prevent permanent disability or death. It involves sudden, progressive, and often life-threatening disturbances in vital body functions, such as cardiovascular, respiratory, or neurological disorders. The Vasoactive-Inotropic Score (VIS) is a clinical tool used to assess the need for vasoactive and inotropic drugs in critically ill patients. The VIS plays an important role as a prognostic indicator in critically ill patients, with higher VIS scores associated with increased risk of death.

Purpose: To evaluate vasoactive-inotropic score for prediction of critical patient mortality.

Method: A literature review with the aim of reviewing and evaluating previous research related to the use of VIS in predicting mortality in medical emergency patients using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram method. The search for scientific articles was conducted in October-November 2024 by determining the population/problem, intervention, comparison, and outcome (PICO) method. The database search process was carried out through the Publish or Perish application from PubMed, Scopus, Crossref, Semantic Scholar, and CINAHL. Determination of the article year range was focused on articles from 2018-2024 through keywords consisting of ''inotrope'' AND ''predictor'' AND ''mortality'', ''VIS'' AND ''Patient critical ill'', ''VIS'' OR Predictor mortality, ''VIS'' OR ''ICU''.

Results: The Vasoactive-Inotropic Score (VIS) is an effective and practical clinical tool to be used as a predictor of mortality in emergency and critical patients. VIS provides a quantitative picture of the severity of hemodynamic disorders as well as the pharmacological need to maintain the patient's cardiovascular stability. Its use has been shown to be significant in a variety of critical conditions, such as postoperative cardiac surgery, cardiogenic shock, sepsis, and out-of-hospital cardiac arrest, where higher VIS values are often correlated with an increased risk of mortality. The accuracy of VIS in predicting mortality risk can be improved through integration with other clinical parameters, such as inflammatory biomarkers and organ dysfunction scores, which provide a more comprehensive picture of the patient's physiological status.

Conclusion:  VIS is consistently used as a predictive tool with varying morbidity-mortality thresholds in critically ill patients depending on population size. Factors that influence VIS values ​​include patient demographic characteristics, hemodynamic status, disease severity, and quality of therapy received by the patient.

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References

American Heart Association. (2022). Heart and Stroke Statistics: 2022 Update. Retrieved from: https://cpr.heart.org/en/resources/cpr-facts-and-stats

Belletti, A., Lerose, C. C., Zangrillo, A., & Landoni, G. (2021). Vasoactive-inotropic score: evolution, clinical utility, and pitfalls. Journal of cardiothoracic and vascular anesthesia, 35(10), 3067-3077.

Bojan, M., & Pouard, P. (2023). Hemodynamic management. Anesthesia for Congenital Heart Disease, 494-526.

Gutierrez, E. J. (2023). The Vasopressor & Inotrope Handbook: A Practical Guide for Healthcare Professionals. Eddy J. Gutierrez.

Hyland, S. L., Faltys, M., Hüser, M., Lyu, X., Gumbsch, T., Esteban, C., & Merz, T. M. (2020). Early prediction of circulatory failure in the intensive care unit using machine learning. Nature medicine, 26(3), 364-373.

Jeong, J. H., Kook, H., Lee, S. H., Joo, H. J., Park, J. H., Hong, S. J., & Yu, C. W. (2024). Prediction of in‐hospital mortality for ischemic cardiogenic shock requiring venoarterial extracorporeal membrane oxygenation. Journal of the American Heart Association, 13(4), e032701.

Kallekkattu, D., Rameshkumar, R., Chidambaram, M., Krishnamurthy, K., Selvan, T., & Mahadevan, S. (2022). Threshold of inotropic score and vasoactive–inotropic score for predicting mortality in pediatric septic shock. Indian Journal of Pediatrics, 1-6.

Keleş, B. O., Yılmaz, E. T., Altınbaş, A., Zengin, S., & Yılmaz, S. (2024). When is the ideal time to calculate the Vasoactive Inotropic Score as a predictor of mortality and morbidity in cardiac surgery? A retrospective study. Annals of Cardiac Anaesthesia, 27(1), 37-42.

Koponen, T., Karttunen, J., Musialowicz, T., Pietiläinen, L., Uusaro, A., & Lahtinen, P. (2019). Vasoactive-inotropic score and the prediction of morbidity and mortality after cardiac surgery. British journal of anaesthesia, 122(4), 428-436.

Llwyd, O., Fan, J. L., & Müller, M. (2022). Effect of drug interventions on cerebral hemodynamics in ischemic stroke patients. Journal of Cerebral Blood Flow & Metabolism, 42(3), 471-485.

McPhail, S., Swann, R., Johnson, S. A., Barclay, M. E., Abd Elkader, H., Alvi, R., & You, H. (2022). Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation): an International Cancer Benchmarking Partnership (ICBP) population-based study. The lancet oncology, 23(5), 587-600.

Mete, E. M. T., Bastopcu, M., & Acarel, M. (2023). 24th hour vasoactive inotrope score is associated with poor outcome in adult cardiac surgery. Revista da Associação Médica Brasileira, 69, e20221433.

Na, S. J., Chung, C. R., Cho, Y. H., Jeon, K., Suh, G. Y., Ahn, J. H., & Yang, J. H. (2019). Vasoactive inotropic score as a predictor of mortality in adult patients with cardiogenic shock: medical therapy versus ECMO. Revista Española de Cardiología (English Edition), 72(1), 40-47.

Nickson, A. (2023). Collapse and sudden illness. RCEM Lecture Notes: Emergency medicine, 233-276.

Oh, Y. T., Oh, J., Park, S. M., Kim, Y. J., Jo, Y. H., Yang, H. C., Lee, Y. H., & Lee, D. K. (2019). Vasoactive-inotropic score as a predictor of in-hospital mortality in out-of-hospital cardiac arrest. Signa Vitae: Journal for Intesive Care and Emergency Medicine, 15(2), 40–44.

Rojas‐García, A., Turner, S., Pizzo, E., Hudson, E., Thomas, J., & Raine, R. (2018). Impact and experiences of delayed discharge: A mixed‐studies systematic review. Health Expectations, 21(1), 41-56.

Sanchez-Pinto, L. N., Bennett, T. D., DeWitt, P. E., Russell, S., Rebull, M. N., Martin, B., & Wynn, J. L. (2024). Development and validation of the Phoenix criteria for pediatric sepsis and septic shock. Jama, 331(8), 675-686.

Song, J., Cho, H., Park, D. W., Moon, S., Kim, J. Y., Ahn, S., & Park, J. (2021). Vasoactive-inotropic score as an early predictor of mortality in adult patients with sepsis. Journal of clinical medicine, 10(3), 495.

World Health Organization. (2024). Sepsis. Retrieved from: https://www.who.int/news-room/fact-sheets/detail/sepsis

Yamazaki, Y., Oba, K., Matsui, Y., & Morimoto, Y. (2018). Vasoactive-inotropic score as a predictor of morbidity and mortality in adults after cardiac surgery with cardiopulmonary bypass. Journal of anesthesia, 32, 167-173.

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Published

2025-04-27

How to Cite

Vasoactive-inotropic score for prediction of critical patient mortality: A systematic review. (2025). MIN, 8(2), 219-228. https://doi.org/10.33024/minh.v8i2.481