The effect of FeUP (Fe uptake package) box on adherence to iron tablet intake among adolescent girls with anemia

DOI: https://doi.org/10.33024/minh.v9i5.3852

Authors

  • Dinda Puput Purwanti Program Studi Keperawatan Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia
  • Linda Amalia Program Studi Keperawatan, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia
  • Afianti Sulastri Program Studi Keperawatan Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia

Adherence Adolescent Girls Anemia FeUP Box Iron Tablets

Abstract

Background: Anemia remains a major health problem among adolescent girls. Although the distribution of iron tablets continues to expand, adherence remains low due to forgetfulness, lack of motivation, and insufficient monitoring. The FeUP (Fe uptake package) Box is an integrated adherence support intervention that combines a pill box, educational and instruction cards, a self monitoring card, and parental involvement to simultaneously address these barriers and improve adherence to iron tablet intake.

Purpose: To analyze the effectiveness of the FeUP box in improving adherence to iron tablet intake among adolescent girls with anemia.

Method: A quasi-experimental study was conducted using a nonequivalent control group with a pretest–posttest design. Participants were selected through purposive sampling from SMPN 29 Bandung, within the Ledeng Community Health Center service area, and SMPN 2 Parongpong, within the Ciwaruga Community Health Center service area. The sample consisted of 52 adolescent girls diagnosed with anemia, divided equally into an intervention group (n = 26) and a control group (n = 26). Adherence to iron tablet consumption was assessed using the Morisky Medication Adherence Scale-8 (MMAS-8). The intervention group received FeUP Box educational materials for four weeks, while the control group followed the school’s standard iron supplementation program without additional education. Data analysis employed the Wilcoxon Signed-Rank Test to examine within-group changes in adherence and the Mann-Whitney U Test to compare adherence outcomes between the intervention and control groups.

Results: Adherence scores in the intervention group increased from 3.57 ± 1.37 (95% CI: 3.01–4.12) to 5.25 ± 1.23 (95% CI: 4.75–5.75) after the intervention, with a significant improvement (p < 0.001; r = 0.692). In contrast, no significant change was observed in the control group, with adherence scores changing from 3.04 ± 1.46 (95% CI: 2.45–3.63) to 2.86 ± 1.33 (95% CI: 2.32–3.39) (p = 0.317; r = 0.196). The increase in adherence scores was significantly greater in the intervention group than in the control group (p < 0.001; r = 0.585). As a supporting objective measure, hemoglobin levels in the intervention group showed an upward trend after the intervention; however, the increase was not statistically significant.

Conclusion: The FeUP box effectively improved adherence to iron tablet intake among adolescent girls with anemia. Integrating the FeUP box into school-based iron supplementation programs may provide a practical strategy to strengthen adherence and support anemia prevention among adolescent girls.

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Author Biographies

  • Dinda Puput Purwanti, Program Studi Keperawatan Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia

    Mahasiswa, Program Studi Keperawatan Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia

  • Linda Amalia, Program Studi Keperawatan, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia

    Dosen, Program Studi Keperawatan Universitas Pendidikan Indonesia

  • Afianti Sulastri, Program Studi Keperawatan Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia

    Dosen, Program Studi Keperawatan Fakultas Pendidikan Olahraga dan Kesehatan Universitas Pendidikan Indonesia

References

Alhadi, A. (2023). Hubungan pengetahuan dan sikap dengan kepatuhan konsumsi tablet tambah darah pada siswi SMAN 10 di wilayah kerja Puskesmas Andalas Kota Padang (Doctoral dissertation, Universitas Muhammadiyah Sumatera Barat).

Al Mufarid, M. R., Herviana, H., & Fadli, S. (2026). Pemberdayaan teman sebaya dalam pemantauan konsumsi tablet tambah darah pada remaja putri di sekolah: Jurnal Pengabdian Kepada Masyarakat: Kesehatan, 6(1), 51-57.

Amalia, L., Yunitasari, E., & Pragholapati, A. (2026). Analysis of dietary consumption patterns affecting iron absorption in adolescent girls. International Journal of High Risk Behaviors & Addiction, 15(1), 1.

Amperatmoko, A. S., Apriningsih, A., Makkiyah, F. A., & Wahyuningtyas, W. (2022). Perbedaan efektivitas penggunaan jenis media edukasi tentang anemia terhadap pengetahuan, sikap, efikasi diri remaja putri Desa Sirnagalih. Jurnal kesehatan komunitas (Journal of community health), 8(1), 146-153.

Becker, M. H. (1974). The health belief model and sick role behavior. Health education monographs, 2(4), 409-419.

Bumpus, P. J., Rogers, J. L., & Rust, M. S. (2024). Individualized medication card assists the elderly with medication understanding and adherence. Journal of Nursing Education and Practice, 15(2), 10.

Cohen, C. T., & Powers, J. M. (2024). Nutritional strategies for managing Iron deficiency in adolescents: approaches to a challenging but common problem. Advances in Nutrition, 15(5), 100215.

Cohen, J. (1977). Statistical power analysis for the behavioral sciences, Rev. Lawrence Erlbaum Associates, Inc.

Communication and Information Office of West Java Province. (2025). Sekitar 40 persen remaja putri alami anemia, Pemkot Program pemberian tablet tambah darah gratis. retrieved from: https://www.jabarprov.go.id/berita/sekitar-40-persen-remaja-putri-alami-anemia-pemkot-program-pemberian-tablet-tambah-darah-22195.

Damayanti, F., Kusharisupeni, K., Adawiyah, A. R., & Hymawati, H. (2025). Determinan kepatuhan mengonsumsi tablet tambah darah (TTD) pada remaja putri di SMAN 02 Gunung Putri Kabupaten Bogor. Jurnal Untuk Masyarakat Sehat (JUKMAS), 9(1), 15-31.

Dhurde, V. S., Patel, A. B., Locks, L. M., & Hibberd, P. L. (2024). Anaemia prevalence, its determinants and profile of micronutrient status among rural school adolescent girls aged 14–19 years: a cross-sectional study in Nagpur district, Maharashtra, India. Public health nutrition, 27(1), e248.

Ezliana, E., Hapisah, H., Megawati, M., & Rusmilawaty, R. (2024). The effectiveness of using the Aplikasi Sahabat Remaja Indonesia (ASRI) and Whatsapp reminder on compliance with beautiful pill consumption in teenage girl at SMKN 3 Banjarbaru. Jurnal Kebidanan Bestari, 8(2), 77-84.

Fahrunisa, A., Ekasari, T., & Ermawati, I. (2024). Hubungan kepatuhan konsumsi tablet tambah darah dengan kejadian anemia pada remaja putri. Jurnal Bidan Komunitas, 7(1), 40-45.

Falah, M., Lismayanti, L., Sari, N. P., Setiawan, A., Restiana, N., Sasyari, U., & Munirah, M. (2022). Effectiveness of application of daily medicine boxes to compliance with anti-tuberculosis drug consumption in Indonesian tuberculosis patients. South East Asia Nurs Res, 4, 25.

Firdawati, F. (2023). Pengaruh media explosion box terhadap pengetahuan dan kepatuhan konsumsi tablet tambah darah remaja putri di MTs Al-Muhajirin Loa Janan. (Skripsi Sarjana, Poltekkes Kemenkes Kalimantan Timur).

Fraenkel, J. R., & Wallen, N. E. (1990). How to design and evaluate research in education. Order Department, McGraw Hill Publishing Co., Princeton Rd., Hightstown, NJ 08520.

Ge, P., Liu, S. T., Xu, S. X., Zhang, J. Z., Lai, Y. J., Fu, R. C., & Wu, Y. B. (2022). The influence of parents on medication adherence of their children in China: a cross-sectional online investigation based on health belief model. Frontiers in Public Health, 10, 845032.

Mesalina, R., Dariani, L., & Rahmai, S. L. (2024). Analysis of implementation of ferrous tablets supplementation program for adolescent girl ini Bukittinggi. Journal of Midwifery, 9(2), 45-59.

Ministry of Health of the Republic of Indonesia. (2023). Buku saku pencegahan anemia pada ibu hamil dan remaja putri. Kementerian Kesehatan Republik Indonesia. Retrieved from: https://repository.kemkes.go.id/book/841

Nabila, A. P. (2024). Edukasi dan pemberian kartu pemantauan konsumsi tablet tambah darah pada remaja putri SMP X. Jurnal Kesehatan Tambusai, 5(2), 4780-4786.

Nabila, P. (2026, March 15). Anemia pada remaja putri: Tantangan pencegahan melalui konsumsi tablet tambah darah. Badan Kebijakan Pembangunan Kesehatan Kemenkes. Retrieved from: https://www.badankebijakan.kemkes.go.id/anemia-pada-remaja-putri-tantangan-pencegahan-melalui-konsumsi-tablet-tambah-darah/

Okam, M. M., Koch, T. A., & Tran, M. H. (2017). Iron supplementation, response in iron-deficiency anemia: analysis of five trials. The American journal of medicine, 130(8), 991-e1.

Pantopoulos, K. (2024). Oral iron supplementation: new formulations, old questions. Haematologica, 109(9), 2790.

Paranduk, E., Duhita, F., Isir, M., & Abdullah, V. I. (2024). Peningkatan kepatuhan konsumsi tablet tambah darah pada remaja putri melalui edukasi dengan metode pakem di SMP Roon Kabupaten Teluk Wondama. GIAT Noken, 1(1), 31-37.

Public Relation of West Java Province. (2022, November 9). Pemdaprov Jabar - nutrisi internasional konsisten cegah anemia. Gapura Jabar. Retrieved from: https://jabarprov.go.id/berita/pemdaprov-jabar-nutrisi-internasional-konsisten-cegah-anemia-7550

Rahim, E., Daud, S., Ottay, C. J., Sau, R. A., & Ismail, N. R. (2025). Efektivitas teh fortifikasi daun kelor dan kayu manis terhadap hemoglobin remaja putri anemia di SMP Negeri 8 Kota Tengah, Kota Gorontalo. Journal Health & Science: Gorontalo Journal Health and Science Community, 9(4), 363-373.

Rakanita, Y., Sinuraya, R. K., Alfian, S. D., Suradji, E. W., Suwantika, A. A., Anggun, A. S. M. R., & Abdulah, R. (2023). Adherence does not guarantee the outcome of iron supplementation for reproductive-age women with anemia in West Papua Province, Indonesia: A quasi-experimental study. International Journal of Women’s Health and Reproduction Sciences, 11(1), 3-10.

Ristanti, Y. E., & Fatimah, J. (2023). Hubungan peran serta kader, peran bidan dan motivasi dengan kepatuhan konsumsi tablet Fe untuk persiapan reproduksi remaja putri di Desa Ciherang tahun 2022. SENTRI: Jurnal Riset Ilmiah, 2(5), 1649-1662.

Roy, S., Ramaiah, B., & Prabhudev, B. R. (2024). A prospective study on effectiveness of using pill count boxes/organisers to improve medication adherence. International Journal of Pharmaceutical Research and Applications, 9(2), 566-572. Retrieved from: https://doi.org/10.35629/7781-0902566572

Rusmiati, D., Ama, P. G. B., & Wahyuni, D. (2025). Efektivitas suplementasi tablet tambah darah dalam meningkatkan kadar hemoglobin remaja putri. Jurnal Ilmiah Kesehatan, 17(2), 85-95.

Safari, Y., Suprapti, B., Libriansyah, L., & Bernadus, Z. G. (2025). Comparative analysis of medication reminder chart and pill box in improving medication adherence and clinical outcome of diabetic patients. Journal of Pharmacy and Pharmacognosy Research, 13(5), 1600-1606.

Setiani, L. A., Nurdin, N. M., & Rakasiwi, I. A. (2021). Pengaruh pemberian pill card terhadap kepatuhan minum obat dan tekanan darah pasien hipertensi di RS PMI Kota Bogor. FITOFARMAKA: Jurnal Ilmiah Farmasi, 11(1), 51-66.

Tresnowati, G. I., Kusuma, I. Y., & Sunarti, S. (2022). Monitoring of medication compliance in type 2 diabetes mellitus patients with media adherence pill box unit daily dose. JFIOnline| Print ISSN 1412-1107| e-ISSN 2355-696X, 14(2), 97-104.

Utami, A., Margawati, A., Pramono, D., Julianti, H. P., Adespin, D. A., & Wulandari, D. R. (2022). The effectiveness of iron-folic acid supplementation and education intervention to hemoglobin level, knowledge, and compliance among adolescent girls in Islamic boarding school. Open Access Macedonian Journal of Medical Sciences, 10(E), 1141-1146.

Utami, A. P., & Sudaryanto, A. (2025). Kepatuhan konsumsi tablet tambah darah dengan kejadian anemia pada remaja putri. JIK Jurnal Ilmu Kesehatan, 9(1), 104-110.

Wahyunita, S., Rosyadi, M. I., & Fakhrani, E. (2025). The effect of compliance in education pill box on the success of hypertension treatment in Alalak Tengah Puskesmas. Journal of Pharmaceutical and Sciences, 1690-1697.

Weckmann, G., Kiel, S., Chenot, J. F., & Angelow, A. (2023). Association of anemia with clinical symptoms commonly attributed to anemia—analysis of two population-based cohorts. Journal of Clinical Medicine, 12(3), 921.

World Health Organization. (2007). BMI-for-age (5–19 years). Retrieved from: https://www.who.int/tools/growth-reference-data-for-5to19-years/indicators/bmi-for-age

World Health Organization. (2011). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Retrieved from: https://www.who.int/publications/i/item/WHO-NMH-NHD-MNM-11.1

World Health Organization. (2025). WHO global anaemia estimates: Key findings, 2025. Retrieved from: https://www.who.int/publications/i/item/9789240113930

Yang, C., Huang, R., Tao, Q., Hao, Z., Zhao, L., & Zhang, L. (2025). Pathways linking parental social support and decision‐making participation to medication adherence in children with epilepsy: The moderating role of parental anxiety. Depression and Anxiety, 2025(1), 7159579.

Yuliani, R., Handayani, L., & Mariana, F. (2024, September). “Pena sahabat” (Pengawas minum tablet tambah darah) di MTs Siti Khadijah wilayah kerja Puskesmas Tapin Utara. Prosiding Seminar Nasional Masyarakat Tangguh (Vol. 3, No. 1, pp. 484-494).

Yusufu, I., Cliffer, I. R., Yussuf, M. H., Anthony, C., Mapendo, F., Abdulla, S., & Fawzi, W. (2023). Factors associated with anemia among school-going adolescents aged 10–17 years in Zanzibar, Tanzania: A cross sectional study. BMC Public Health, 23(1), 1814.

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Published

2026-07-29

How to Cite

The effect of FeUP (Fe uptake package) box on adherence to iron tablet intake among adolescent girls with anemia. (2026). MIN, 9(5), 824-836. https://doi.org/10.33024/minh.v9i5.3852