Utilization of digital health in the screening, diagnosis, and management of Morbus Hansen

DOI: https://doi.org/10.33024/minh.v9i4.3415

Authors

  • Bagja Prayitno Universitas Jenderal Soedirman
  • Endang Triyanto Universitas Jenderal Soedirman

Artificial Intelligence Diagnosis Digital Health Leprosy mHealth Screening

Abstract

Background: Leprosy (Morbus Hansen) remains a significant global health problem, and delayed detection in areas with limited specialist access continues to drive permanent disability. Digital health offers a promising means of strengthening the screening, diagnosis, and management of the disease in such settings.

Purpose: To summarise the most recent evidence on the implementation of digital technologies in leprosy care. Method: A systematic literature search was conducted in the Scopus, PubMed, ScienceDirect, and EBSCO databases up to 21 November 2025, using the keywords leprosy, digital health, mHealth, artificial intelligence, screening, diagnosis, and management. Eligible studies were original research that evaluated digital tools for the screening, diagnosis, or management of leprosy. Study selection followed the PRISMA 2020 guidelines, and the risk of bias was appraised using the Mixed Methods Appraisal Tool (MMAT).

Results: Of 80 records identified, five studies met the inclusion criteria. These covered an artificial intelligence (AI) web-based application for classifying leprosy type, a mobile application supporting primary health care, an e-Leprosy information system with SMS reminders, a machine-learning algorithm based on the Leprosy Suspicion Questionnaire (MaLeSQs), and the AI4Leprosy diagnostic assistant based on skin images. Reported sensitivity ranged from 85.7% to 93.97% and specificity from 69.2% to 90%.

Conclusion: Digital technologies such as mobile applications, health information systems, and AI can enhance leprosy screening and management. However, most studies remain at an early stage and require field validation and the evaluation of their long-term clinical impact.

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References

Alderton, D. L., Ackley, C., & Trueba, M. L. (2024). The psychosocial impacts of skin neglected tropical diseases (sNTDs) as perceived by the affected persons: A systematic review. PLoS Neglected Tropical Diseases, 18(8), e0012391.

Barbieri, R. R., Xu, Y., Setian, L., Souza-Santos, P. T., Trivedi, A., Cristofono, J., Bhering, R., White, K., Sales, A. M., Miller, G., Nery, J. A. C., Sharmah, M., Bumann, R., Zhang, S., Goldust, M., Sarno, E. N., Mirza, F., Cavaliero, A., Timmer, S., Bongfiglioli, E., Smith, C., Scollard, D., Nvarani, A. A., Aerts, A., Ferres, J. V., & Moraes, M. (2022). Reimagining leprosy elimination with AI analysis of a combination of skin lesion images with demographic and clinical data. The Lancet Regional Health – Americas, 9, 100192.

Barnowska, E. J., Fastenau, A., Penna, S., Bonkass, A. K., Stuetzle, S., & Janssen, R. (2024). Diagnosing skin neglected tropical diseases with the aid of digital health tools: A scoping review. PLOS Digital Health, 3(10).

Carrion, C., Robles, N., Sola-Morales, O., Aymerich, M., & Ruiz Postigo, J. A. (2020). Mobile health strategies to tackle skin neglected tropical diseases with recommendations from innovative experiences: Systematic review. JMIR mHealth and uHealth, 8(12).

Dahoklory, D. F., Haryanto, J., & Indarwati, R. (2023). The application of digital health as a nursing solution for leprosy patients during the COVID-19 pandemic: A systematic review. JPMA. The Journal of the Pakistan Medical Association, 73(2), S170-S174.

De Andrade, R. R. S, Heise, E. F. J., Hartmann, L. F., Rocha, G. E., Olandoski, M., de Araújo, S. M. M, Latini, A. C. P., Soares, C. T., Belone, A, Rosa, P. S, de Andrade, P. M. A., de Sá, G. H., Cruz, R., Penna, M. L. F., Carvalho, D. R., Fava, V. M., Bührer-Sékula, S., Penna, G. O., Moro, C. M. C., Nievola, J. C., & Mira, M. T. (2023). Prediction of the occurrence of leprosy reactions based on Bayesian networks. Frontries Medicine, 10.

Deps, P., Yotsu, R., Furriel, R., de Oliveira, D. A., de Lima, J., & Loureiro, S. M. (2024). The potential role of artificial intelligence in the clinical management of Hansen's disease (leprosy). Frontiers in Medicine, 11.

De Souza, M. L. M., Lopes, G. A., Branco, A. C., Fairley, J. K., & Fraga, L. A. D. O. (2021). Leprosy screening based on artificial intelligence: development of a cross-platform app. JMIR mHealth and uHealth, 9(4).

Fernandes, J. R. N., Teles, A. S., Fernandes, T. R. S., Lima, L. D. B., Balhara, S., Gupta, N., & Teixeira, S. (2023). Artificial intelligence on diagnostic aid of leprosy: a systematic literature review. Journal of clinical medicine, 13(1), 180.

Joshi, T. P., & Ren, V. (2021). Teledermatology in the control of skin neglected tropical diseases: A systematic review. Dermatology Practical & Conceptual, 11(4).

Lynn, T., Gomes Vilar de Andrade, H., da Silva Rocha, E., de Carvalho Monteiro, K. H., Matos de Morais, C., Moura dos Santos, D. C., Cassimiro Nascimento, D., Dourado, R. A., & Takako Endo, P. (2025). On the usage of artificial intelligence in leprosy care: A systematic literature review. PLoS Computational Biology, 21(6).

Matos, D. P., Torres, M. D., da Silva, L. S. R., Dos Santos, C. A. A. S., de Oliveira, F. J. F., de Araújo, M. F. M., & de Oliveira Serra, M. A. A. (2022). Hansenapp: Development of a mobile application to assist primary healthcare providers to control leprosy. Tropical medicine & international health : TM & IH, 27(8), 719–726.

Mwageni, N., van Wijk, R., Daba, F., Mamo, E., Debelo, K., Jansen, B., Schoenmakers, A., van Hees, C. L. M., Kasang, C., Mieras, L., & Mshana, S. E. (2024). The NLR SkinApp: Testing a supporting mHealth tool for frontline health workers performing skin screening in Ethiopia and Tanzania. Tropical Medicine and Infectious Disease, 9(1), 18.

Quilter, E. E., Butlin, C. R., Carrion, C., & Ruiz-Postigo, J. A. (2024). The WHO Skin NTD mobile application–a paradigm shift in leprosy diagnosis through Artificial Intelligence?. Leprosy Review, 95(2), 0-0.

Rachmani, E., Lin, M. C., Hsu, C. Y., Jumanto, J., Iqbal, U., Shidik, G. F., & Noersasongko, E. (2020). The implementation of an integrated e-leprosy framework in a leprosy control program at primary health care centers in Indonesia. International Journal of Medical Informatics, 140, 104155.

Simões, M. R., Lima, F. R., Lugão, H. B., de Paula, N. A., Silva, C. M. L., Ramos, F. A., & Frade, M. A. C. (2025). Development and validation of a machine learning approach for screening new leprosy cases based on the leprosy suspicion questionnaire. Scientific Reports, 15(1), 6912.

Solanki, A., & Chaurasia, A. (2025). Mapping digital health technologies for leprosy in South Asia: a scoping review. International Journal of Advanced Health Science and Technology, 5(2), 40-53.

White, C., & Franco-Paredes, C. (2015). Leprosy in the 21st century. Clinical Microbiology Reviews, 28(1), 80–94.

World Health Organization. (2024). Global leprosy (Hansen disease) update, 2023: Elimination of leprosy disease is possible—Time to act! Weekly Epidemiological Record, 99(37), 501–521.

Yotsu, R. R., Almamy, D., Vagamon, B., Ugai, K., Itoh, S., Koffi, Y. D., Kaloga, M., Dizoé, L. A. S., Kouadio, K., Aka, N., Yeboue, L. K. G., Yao, K. A., & Blanton, R. E. (2023). An mHealth app (eSkinHealth) for detecting and managing skin diseases in resource-limited settings: Mixed methods pilot study. JMIR Dermatology, 6, e46295.

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Published

2026-07-03

How to Cite

Utilization of digital health in the screening, diagnosis, and management of Morbus Hansen. (2026). MIN, 9(4), 628-636. https://doi.org/10.33024/minh.v9i4.3415