The relationship between HbA1c levels and erythrocyte sedimentation rate in type 2 diabetes mellitus patients based on hypertension status
DOI: https://doi.org/10.33024/minh.v9i3.2856
Erythrocyte Sedimentation Rate HBA1C Level Type 2 Diabetes Mellitus
Abstract
Background: Measuring random or fasting blood glucose levels does not fully reflect the quality of long-term blood glucose control. Therefore, more accurate monitoring of glycemic status in patients with diabetes mellitus is performed through the HbA1c test. This test is used as an indicator of successful diabetes mellitus control and to minimize the risk of cardiovascular complications and improve patients' quality of life.
Purpose: To determine the relationship between HbA1c levels and erythrocyte sedimentation rate (ESR) values in type 2 Diabetes Mellitus patients based on hypertension status at the Bunda Thamrin Medical Laboratory, Medan.
Method: A quantitative approach was employed with a descriptive correlational analytical design. The population was 70 patients with type 2 diabetes mellitus, with a sample size of 70 obtained through a specific sampling method. Data on HbA1c levels and ESR values were analyzed to determine their relationship to the patients' hypertension status.
Results: No significant differences in HbA1c levels (p=0.746) or ESR values (p=0.259) were found between the hypertensive and normotensive patient groups. However, a clinically significant trend was found in ESR values, with the hypertensive group having a higher proportion of normal ESR values (p=0.066).
Conclusion: No significant differences were found between HbA1c levels and ESR values based on hypertension status. Nevertheless, HbA1c has the potential to be an indirect predictor of inflammatory status. Optimal glycemic control remains crucial to reduce the risk of cardiovascular complications through anti-inflammatory mechanisms, especially in patients with hypertension who require more comprehensive management.
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References
Akın, S., & Bölük, C. (2020). Prevalence of comorbidities in patients with type–2 diabetes mellitus. Primary care diabetes, 14(5), 431-434.
Al-hashimi, H., Merie, G., & Mustafa, M. (2025). The Relationship Between HbA1c and Diabetes. Pharaonic Journal of Science, 1(1), 46-60.
Argano, C., & Scaglione, R. (2025). Advances in diabetes and hypertension research. Frontiers in Endocrinology, 16, 1711423.
Berbudi, A., Rahmadika, N., Tjahjadi, A. I., & Ruslami, R. (2020). Type 2 diabetes and its impact on the immune system. Current diabetes reviews, 16(5), 442-449.
Bertoluci, M. C., Silva Junior, W. S., Valente, F., Araujo, L. R., Lyra, R., de Castro, J. J., & Carvalho, D. (2023). 2023 UPDATE: Luso-Brazilian evidence-based guideline for the management of antidiabetic therapy in type 2 diabetes. Diabetology & Metabolic Syndrome, 15(1), 160.
Boye, K. S., Thieu, V. T., Lage, M. J., Miller, H., & Paczkowski, R. (2022). The association between sustained HbA1c control and long-term complications among individuals with type 2 diabetes: a retrospective study. Advances in Therapy, 39(5), 2208-2221.
Caillon, A., Paradis, P., & Schiffrin, E. L. (2019). Role of immune cells in hypertension. British journal of pharmacology, 176(12), 1818-1828.
Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., & Rena, G. (2016). Anti-inflammatory effects of metformin irrespective of diabetes status. Circulation research, 119(5), 652-665.
Ceriello, A., & Prattichizzo, F. (2021). Variability of risk factors and diabetes complications. Cardiovascular diabetology, 20(1), 101.
Charles, C. E., Onuoha, U. S., Oso, G., Agongo, S., & Ordinoha, B. (2025). Health-Care Seeking Behaviour among Diabetes Patients in Umuiahia, Abia State. Batna Journal of Medical Sciences (BJMS), 12(2), 201–210.
Dancey, C. P., & Reidy, J. (2007). Statistics without maths for psychology. Pearson education.
DiMeglio, L. A., Acerini, C. L., Codner Dujovne, E., Craig, M. E., Hofer, S. E., Pillay, K., & Maahs, D. M. (2018). ISPAD Clinical Practice Consensus Guidelines 2018: Glycemic control targets and glucose monitoring for children, adolescents, and young adults with diabetes.
Elbaruni, K., Abdulwahed, E., Khalfalla, W., Alsudany, R., Jerbi, R., Alwaseea, N., & Abuagela, M. (2023). Association between some inflammatory markers and HbA1c in patients with type 2 diabetes mellitus. AlQalam Journal of Medical and Applied Sciences, 137-141.
ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., & Gabbay, R. A. (2022). Introduction and methodology: standards of care in diabetes—2023. Diabetes care, 46(Suppl 1), S1.
Galantini, M. P. L., Ribeiro, I. S., Gonçalves, C. V., Muniz, I. P. R., Lima, P. H. B., Santos, G. S., & da Silva, R. A. A. (2022). The sweet fuel of inflammation: New perspectives on the complex web that interconnects diabetes. Experimental gerontology, 167, 111905.
González, P., Lozano, P., Ros, G., & Solano, F. (2023). Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. International journal of molecular sciences, 24(11), 9352.
Hankosky, E. R., Schapiro, D., Gunn, K. B., Lubelczyk, E. B., Mitroi, J., & Nelson, D. R. (2023). Gaps remain for achieving HbA1c targets for people with type 1 or type 2 diabetes using insulin: results from NHANES 2009–2020. Diabetes Therapy, 14(6), 967-975.
Kaiafa, G., Veneti, S., Polychronopoulos, G., Pilalas, D., Daios, S., Kanellos, I., & Savopoulos, C. (2021). Is HbA1c an ideal biomarker of well-controlled diabetes?. Postgraduate medical journal, 97(1148), 380-383.
Khunti, K., Gomes, M. B., Pocock, S., Shestakova, M. V., Pintat, S., Fenici, P., & Medina, J. (2018). Therapeutic inertia in the treatment of hyperglycaemia in patients with type 2 diabetes: a systematic review. Diabetes, Obesity and Metabolism, 20(2), 427-437.
Lambrinoudaki, I., Paschou, S. A., Armeni, E., & Goulis, D. G. (2022). The interplay between diabetes mellitus and menopause: clinical implications. Nature Reviews Endocrinology, 18(10), 608-622.
Latif, P. A., Anggraeni, R., & Ismarwati, I. (2025). Korelasi Hasil HbA1C dengan Laju Endap Darah pada Pasien Diabetes Melitus Tipe 2 di RSA UGM Yogyakarta. GALENICAL: Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh, 4(5), 69-80.
Mehta, M., Prasad, A., Kalapureddy, V., Narayanam, H., & Kondaveeti, S. B. (2025). “Insights into HbA1c: Key Role in Diabetes Screening and Associated Conditions”-A Comprehensive Review. Journal of Pharmacy and Bioallied Sciences, 17(Suppl 2), S1064-S1066.
Ministry of Health of the Republic of Indonesia. (2023). Survei Kesehatan Indonesia (SKI) 2023. Retrieved from: https://www.badankebijakan.kemkes.go.id/hasil-ski-2023/
Oktora, S. I., & Butar, D. B. (2022). Determinants of diabetes mellitus prevalence in Indonesia. Jurnal Kesehatan Masyarakat, 18(2), 266-273.
Park, J., Han, K., Lee, K., Chang, Y., & Shin, D. W. (2025, April). Risk of Cardiovascular Disease According to the Precedence Relationship Between Hypertension and Diabetes Mellitus. In Healthcare (Vol. 13, No. 7, p. 796). MDPI.
Riviani, R., Mutiara, E., Santosa, H., & Masyitah, A. (2025). Analisis Spasial Kasus Diabetes Melitus dan Faktor Risiko di Provinsi Sumatera Utara Tahun 2023: Penelitian. Jurnal Pengabdian Masyarakat Dan Riset Pendidikan, 4(1), 972-979.
Sari, E. P., & Sayekti, S. (2023). Korelasi kadar hba1c dengan c-reactive protein pasien diabetes melitus tipe 2. Jurnal Sintesis: Penelitian Sains, Terapan Dan Analisisnya, 4(1).
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., & Magliano, D. J. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes research and clinical practice, 183, 109119.
Tan, A. Y. F., Schneck, K., Garhyan, P., Chan, E. C. Y., & Tham, L. S. (2025). Evaluation of Four Semi‐Mechanistic Models for Predicting Glycemic Control With a Glucagon Receptor Antagonist in People With Type 2 Diabetes. CPT: Pharmacometrics & Systems Pharmacology, 14(8), 1381-1390.
World Health Organization. (2025). Diabetes. Retrieved from: https://www.who.int/health-topics/diabetes#tab=tab_1
Zakir, M., Ahuja, N., Surksha, M. A., Sachdev, R., Kalariya, Y., Nasir, M., & Ali, M. (2023). Cardiovascular complications of diabetes: from microvascular to macrovascular pathways. Cureus, 15(9).
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