Enhancing medication compliance in schizophrenia through peer support and motivational interviewing
DOI: https://doi.org/10.33024/minh.v8i9.1776
Motivational Interviewing Peer Support Schizophrenia Treatment Compliance
Abstract
Background: Schizophrenia is a chronic mental disorder that requires long-term and continuous treatment. One of the major barriers to optimal recovery is non-adherence to treatment, which frequently leads to relapse, prolonged hospitalization, and reduced functional outcomes. Psychosocial approaches, particularly peer group support and motivational interviewing (MI), have been widely applied to strengthen treatment adherence. However, a systematic synthesis that integrates the effectiveness of these two interventions has not been well established.
Purpose: This systematic review aims to identify and analyze the effects of peer group support and motivational interviewing on improving treatment adherence among patients with schizophrenia.
Method: A systematic review approach based on PRISMA guidelines. Article searches were conducted through Scopus, PubMed, and ScienceDirect using the keywords “motivational interviewing”, “peer support”, “medication adherence”, and “schizophrenia”. A total of 1.902.305 articles were identified, and after screening through inclusion and exclusion criteria followed by quality assessment using CASP and the JBI Checklist, 12 studies were selected for final synthesis.
Results: Of the 12 included studies, seven used randomized controlled trial (RCT) designs and five used quasi-experimental designs. Most interventions demonstrated significant improvements in medication adherence. Both peer support interventions and motivational interviewing showed positive and consistent effects on enhancing treatment adherence among individuals with schizophrenia.
Conclusion: Peer group support and motivational interviewing were found to be effective strategies for increasing treatment adherence in patients with schizophrenia. Short-term interventions delivered intensively can produce meaningful improvements, while longer implementation durations tend to yield more stable outcomes. These approaches are recommended for integration into community-based psychiatric nursing practice.
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References
Alinda, N., & Safrudin, M. B. (2025). Psychoeducation on mental health on the self-acceptance of patients after schizophrenia treatment. Jurnal Ilmiah Kesehatan (JIKA), 7(1), 90–99.
Bighelli, I., Rodolico, A., García-Mieres, H., Pitschel-Walz, G., Hansen, W.-P., Schneider-Thoma, J., Siafis, S., Wu, H., Wang, D., Salanti, G., Furukawa, T. A., Barbui, C., & Leucht, S. (2021). Psychosocial and psychological interventions for relapse prevention in schizophrenia: A systematic review.
Davidson, L., Bellamy, C., Guy, K., & Miller, R. (2012). Peer support among persons with severe mental illnesses: A review of evidence and experience. World Psychiatry, 11(2), 123–128.
Fitryasari, R., Nursalam, N., Yusuf, A., Hargono, R., Lin, E. C. L., & Tristiana, R. D. (2021). Development of a family resiliency model to care of patients with schizophrenia. Scandinavian Journal of Caring Sciences, 35(2), 642–649.
Gowda, G. S., & Isaac, M. K. (2022). Models of care of schizophrenia in the community—an international perspective. Current Psychiatry Reports, 24(3), 195–202.
Kementerian Kesehatan Republik Indonesia. (2019). Laporan nasional Riskesdas 2018. Badan Penelitian dan Pengembangan Kesehatan (Balitbangkes), Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan.
Kline, E. R., Thibeau, H., Sanders, A. S., English, K., Davis, B. J., Fenley, A. R., & Keshavan, M. S. (2021). Motivational interviewing for loved ones in early psychosis: Development and pilot feasibility trial of a brief psychoeducational intervention for caregivers. Frontiers in Psychiatry, 12, 659568.
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration. BMJ, 339, b2700.
Loots, E., Goossens, E., Vanwesemael, T., Morrens, M., Van Rompaey, B., & Dilles, T. (2021). Interventions to improve medication adherence in patients with schizophrenia or bipolar disorders: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 18(19), 10213.
Lukas, C. A., & Berking, M. (2021). Blending group-based psychoeducation with a smartphone intervention for the reduction of depressive symptoms: Results of a randomized controlled pilot study. Pilot and Feasibility Studies, 7(1), 57.
Miller, W. R., & Rollnick, S. (2012). Motivational interviewing: Helping people change. Guilford Press.
Mulyati, D., Putri, S., Pertiwi, E. R., & Juwita, R. (2025). A qualitative exploration of factors influencing bullying behavior in schools. Malahayati International Journal of Nursing and Health Science, 8(5), 624–629.
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & Prisma Group. (2010). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. International Journal of Surgery, 8(5), 336–341.
Novitasari, N., Safrudin, M. B., & Imamah, N. F. (2025). Psychoeducation about mental health problems on family emotional support patients after schizophrenia treatment. Jurnal Ilmiah Kesehatan (JIKA), 7(1), 207–215.
Nuraini, A., & Hartini, N. (2021). Modifikasi perilaku untuk meningkatkan kepatuhan minum obat pada pasien skizofrenia. Buletin Penelitian Psikologi dan Kesehatan Mental (BRPKM), 1(1), 1–10.
Olivares, J. M., Rodriguez-Martinez, A., Burón, J. A., Alonso-Escolano, D., & Rodriguez-Morales, A. (2008). Cost-effectiveness analysis of switching antipsychotic medication to long-acting injectable risperidone in patients with schizophrenia: A 12- and 24-month follow-up from the e-STAR database in Spain. Applied Health Economics and Health Policy, 6(1), 41–53.
Pademme, D., & Banna, T. (2021). Peer group support terhadap self-efficacy pasien DM tipe II. Jurnal Ilmiah Kesehatan (JIKA), 3(3), 210–216.
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, L. A., Stewart, L. A., Thomas, J., Tricco, A. C., Welch, V. A., Whiting, P., & Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71.
Putra, P. Y., & Fithriyah, I. (2021). Psychoeducation on adherence to treatment of schizophrenia patient during COVID-19 pandemic era. Indian Journal of Forensic Medicine & Toxicology, 15(4), 2138–2144.
Satuhu, N. R., Juniarti, N., & Widianti, E. (2025). The effectiveness of family motivational interviewing in improving families’ ability to motivate people with severe mental illness in Indonesia. Journal of Psychiatric Nursing/Hemşireleri Derneği, 16(2).
Singkali, D. P., Nihayati, H. E., & Margono, H. M. (2019). Kemampuan caregiver merawat klien skizofrenia di Rumah Sakit Daerah Madani Sulawesi Tengah. Jurnal Penelitian Kesehatan "SUARA FORIKES" (Journal of Health Research "Forikes Voice"), 10(3), 239–242.
Vancampfort, D., Firth, J., Correll, C. U., Solmi, M., Siskind, D., De Hert, M., Carney, R., Koyanagi, A., Carvalho, A. F., Gaughran, F., & Stubbs, B. (2021). The impact of pharmacological and non-pharmacological interventions to improve physical health outcomes in people with schizophrenia: A meta-review of meta-analyses of randomized controlled trials. Focus, 19(1), 116–128.
Vanderwaal, F. M. (2015). Impact of motivational interviewing on medication adherence in schizophrenia. Issues in Mental Health Nursing, 36(11), 900–904.
World Health Organization. (2022, June 17). Mental health: Strengthening our response. Retrieved from https://www.who.int/mediacentre/factsheets/fs220/en
Wulandari, D., Keliat, B. A., & Hariyati, R. T. S. (2021). Efektivitas family interventions dalam menurunkan risiko relaps pada pasien skizofrenia: A systematic review. Jurnal Kesehatan, 12(3), 441–446.
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