Correlations of alanine and aspartate aminotransferase levels with high-sensitivity C-reactive protein in pediatric patients with beta-thalassemia major
DOI: https://doi.org/10.56922/mchc.v5i5.3916
Beta-Thalassemia Major High-Sensitivity C-Reactive Protein SGOT SGPT Systemic Inflammation
Abstract
Background: Beta-thalassemia major is a hereditary blood disorder characterized by severe anemia requiring lifelong regular blood transfusions. Repeated transfusions may lead to iron overload, which can cause oxidative stress, hepatocellular injury, and chronic inflammation. Serum glutamic-pyruvic transaminase (SGPT) and serum glutamic-oxaloacetic transaminase (SGOT) are commonly used to assess hepatocellular injury, whereas high-sensitivity C-reactive protein (hs-CRP) can detect low-grade systemic inflammation.
Purpose: To determine the correlation between SGPT and SGOT levels and hs-CRP levels in pediatric patients with beta-thalassemia major.
Method: This analytical observational study used a cross-sectional design and secondary data from medical records of pediatric patients with beta-thalassemia major treated at Pringsewu Regional General Hospital. Data were collected in February 2025 from records of patients treated between September and November 2024. A purposive sampling technique was used based on predetermined inclusion and exclusion criteria, resulting in 43 eligible patients. Data were analyzed using the Spearman correlation test with a significance level of p < 0.05.
Results: The mean SGPT, SGOT, and hs-CRP levels were 58.86 ± 30.749 U/L, 55.67 ± 23.551 U/L, and 1.1216 ± 1.19167 mg/L, respectively. A significant positive correlation was found between SGPT and hs-CRP levels (p = 0.025; r = 0.341), indicating a weak positive correlation. A significant positive correlation was also found between SGOT and hs-CRP levels (p = 0.005; r = 0.421), indicating a moderate positive correlation.
Conclusion: SGPT and SGOT levels were significantly and positively correlated with hs-CRP levels in pediatric patients with beta-thalassemia major. These findings suggest that hepatocellular injury and systemic inflammation may occur concurrently in patients with transfusion-dependent beta-thalassemia.
Downloads
References
Agustina, R., Mandala, Z., & Indah, R. N. (2020). Hubungan kadar feritin serum dengan kadar enzim sgot dan sgpt pada pasien thalasemia β mayor. Jurnal Ilmiah Kesehatan Sandi husada, 9(1), 252-257.
Ayukarningsih, Y., Amalia, J., & Nurfarhah, G. (2022). Thalassemia and nutritional status in children. Journal of Health and Dental Sciences, 2(1), 39-52.
Banait, T., Wanjari, A., Danade, V., Banait, S., & Jain, J. (2022). Role of high-sensitivity C-reactive protein (Hs-CRP) in non-communicable diseases: a review. Cureus, 14(10).
Coates, T. D. (2019). Iron overload in transfusion-dependent patients. Hematology 2014, the American Society of Hematology Education Program Book, 2019(1), 337-344.
El-Beshlawy, A., Dewedar, H., Hindawi, S., Alkindi, S., Tantawy, A. A., Yassin, M. A., & Taher, A. T. (2024). Management of transfusion-dependent β-thalassemia (TDT): Expert insights and practical overview from the Middle East. Blood Reviews, 63, 101138.
Farmakis, D., Porter, J., Taher, A., Domenica Cappellini, M., Angastiniotis, M., Eleftheriou, A., & Yardumian, A. (2022). 2021 Thalassaemia
International Federation guidelines for the management of transfusion‐dependent thalassemia. Hemasphere, 6(8), e732.
Ghareghani, A., Nikparvar, M., Rafati, S., Eftekhar, E., & Ghareghani, O. (2023). Value of High-Sensitivity C-Reactive Protein, Chronotropic Index, and Heart Rate Recovery in Predicting Cardiac Iron Overload in Patients with Beta-Thalassemia Major.
Goyal, P., & Choudhary, P. K. (2023). To study the level of serum liver enzymes (SGOT & SGPT) in multitransfused thalassemia major patients. IP International Journal of Medical Paediatrics and Oncology, 6(3), 107-109.
Humaida, R., Budiman, W., & Dewi, A. P. (2022). Hubungan Kadar Ferritin Dengan Kadar Kreatinin Pada Pasien Talasemia Usia 4-13 Tahun. Binawan Student Journal, 4(1), 31-37.
Hussein, G. M., Abdullah, M. A., & Hussein, N. Y. (2023). Association of the changes in hepatic enzymes, bilirubin, and plasma proteins with beta-thalassemia in iron over loaded-patients.
Jabbar, H. K., Hassan, M. K., & Al-Naama, L. M. (2023). Lipids profile in children and adolescents with β-thalassemia major. Hematology, Transfusion and Cell Therapy, 45(4), 467-472.
Kuroda, R., Nogawa, K., Watanabe, Y., Morimoto, H., Sakata, K., & Suwazono, Y. (2021). Association between high-sensitive C-reactive protein and the development of liver damage in Japanese male workers. International Journal of Environmental Research and Public Health, 18(6), 2985.
Moftah, W. M., Mohammed, E. K., Morsy, A. A., & Ibrahim, A. A. (2020). Ischemia modified albumin and C-reactive protein in children with β-thalassemia major. Open Journal of Pediatrics, 10(03), 452.
Purbasari, D., & Lail, N. A. (2024). Kepatuhan konsumsi Terapi Kelasi Besi Dengan Kualitas Hidup Anak Pada Penderita Thalasemia Mayor di RSUD Majalengka. MEJORA Medical Journal Awatara, 2(1), 17-24.
Robila, T., Amirulloh, M. R., & Sampurna, R. H. (2024). Kualitas pelayanan kesehatan pada penyintas thalasemia di Kota Sukabumi. Kebijakan: jurnal ilmu administrasi, 15(02), 284-292.
Sadiq, I. Z., Abubakar, F. S., Usman, H. S., Abdullahi, A. D., Ibrahim, B., Kastayal, B. S., & Hassan, H. A. (2024). Thalassemia: Pathophysiology, diagnosis, and advances in treatment. Thalassemia Reports, 14(4), 81-102.
Suhana, K. H., & Nurvinanda, R. (2023). Faktor Faktor yang Berhubungan dengan Kejadian Thalassemia Beta Mayor pada Anak. Jurnal Penelitian Perawat Profesional, 5(4), 1713-1724.
Sunaidi, Y. (2023). Overview of serum glutamic pyruvic transaminase and serum glutamic oxaloacetic transaminase levels in covid-19 patients. Jurnal Kedokteran Universitas Palangka Raya, 11(1).
Suryoadji, K. A., & Alfian, I. M. (2021). Patofisiologi Gejala Penyakit Thalasemia Beta: A Narrative Review. Khazanah: Jurnal Mahasiswa, 13(2).
Syafira, M., Sribudiani, Y., & Maskoen, A. M. (2024). Systematic Review: Pemodifikasi Genetik Β-Thalassemia. Journal of Medicine and Health, 6(1), 91-102.
Xian, J., Wang, Y., He, J., Li, S., He, W., Ma, X., & Li, Q. (2022). Molecular epidemiology and hematologic characterization of thalassemia in Guangdong Province, Southern China. Clinical and Applied Thrombosis/Hemostasis, 28, 10760296221119807.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 THE JOURNAL OF Mother and Child Health Concerns
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
