Management oral care mengatasi mucositis pada pasien kanker yang menjalani terapi kemo dan radiasi: A systematic review
DOI: https://doi.org/10.33024/hjk.v19i1.765
Kanker Mukosisitis Oral Radiasi Terapi Kemo
Abstract
Background: Oral mucositis (OM) is a common and highly symptomatic complication of cancer therapy that affects the quality of life function. Chemotherapy and radiation are the most widely used interventions in cancer treatment. The prevalence of oral mucositis side effects among 294 head and neck cancer patients was 93.9%.
Purpose: To analyze oral care management to overcome mucositis in cancer patients undergoing chemotherapy and radiation therapy.
Method: Literature review study using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and PICOS approach, P: cancer patients undergoing chemotherapy and radiation, I: oral care management, C: no specific treatment or other standard care, O: reducing severity and accelerating healing, S: randomized controlled trial (RCT). Literature search using keywords “management” AND "oral mucositis" OR “stomatitis” OR “oromucositis” OR “oromucositides” AND "cancer", “management” AND “mucositis” OR “oral mucositis” OR “mucosa inflammation” OR “stomatitis” AND “cancer treatment”.
Results: Various methods have been used to treat oral mucositis in cancer patients undergoing chemotherapy and radiation. Although there are differences in the timing, method, and frequency of mouthwash use, most of the literature shows that mouthwash is effective in reducing oral mucositis in patients.
Conclusion: Management of oral mucositis can be done to treat and prevent oral mucositis in cancer patients currently receiving chemo and radiation therapy.
Keywords: Cancer; Chemotherapy; Mucositis Oral; Radiotherapy.
Pendahuluan: Oral mucositis (OM) merupakan komplikasi umum dan sangat simtomatik dari terapi kanker yang memengaruhi fungsi kualitas hidup. Kemoterapi dan radiasi adalah intervensi paling banyak digunakan dalam pengobatan kanker. Prevalensi efek samping mukositis oral diantara 294 pasien kanker kepala dan leher adalah 93.9%.
Tujuan: Untuk menganalisis management oral care mengatasi mucositis pada pasien kanker yang menjalani terapi kemo dan radiasi.
Metode: Penelitian literature review menggunakan panduan Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) dan pendekatan PICOS, P: pasien kanker yang menjalani kemoterapi dan radiasi, I: manajemen perawatan oral, C: tidak ada perawatan khusus atau perawatan standar lainnya, O: mengurangi keparahan dan mempercepat penyembuhan, S: randomized control trial (RCT). Pencarian literatur menggunakan kata kunci “management” AND "oral mucositis" OR “stomatitis” OR “oromucositis” OR “oromucositides” AND "cancer", “management” AND “mucositis” OR “oral mucositis” OR “mucosa inflammation” OR “stomatitis” AND “cancer treatment”.
Hasil: Berbagai metode telah digunakan untuk mengatasi mukositis oral pada pasien kanker yang menjalani kemoterapi dan radiasi. Meskipun terdapat perbedaan dalam waktu, cara, dan frekuensi penggunaan obat kumur, sebagian besar literatur menunjukkan bahwa obat kumur efektif dalam mengurangi mukositis oral pada pasien.
Simpulan: Manajemen penanganan mukositis oral dapat dilakukan untuk mengatasi dan mencegah mukositis oral pada pasien kanker yang menjalani terapi kemo dan radiasi.
Kata Kunci: Kanker; Mukosisitis Oral; Radiasi; Terapi Kemo.
Downloads
References
Abo El Fadel, D. M., Kamal, Y., Hassouna, A. H., & Ali, A. (2024). Prevalence Of Oral Side Effects Associated With Chemo And Radiotherapy In Head And Neck Cancer Treatment: A Cross-Sectional Study In Egypt. Oral Oncology Reports, 10, 100177.
Alshammari, S. R., Aloteibi, M. A., Aljoufi, M. K., Alharbi, S. S. S., Aldosare, B. M., Alshehri, D. S., & Hayjan, S. A. A. (2024). A Complication Of Radiotherapy-Oral Mucositis: An Updated Review For Healthcare Providers. Journal Of Ecohumanism, 3(8), 13682-13692.
Alsulami, F. J., & Shaheed, S. U. (2022). Oral Cryotherapy For Management Of Chemotherapy‐Induced Oral Mucositis In Haematopoietic Cell Transplantation: A Systematic Review. BMC Cancer, 22(1), 442.
Bezerra, P. M. M., Vieira, T. I., Dos Santos, F. G., Ribeiro, I. L. A., De Sousa, S. A., & Valenca, A. M. G. (2022). The Impact Of Oral Health Education On The Incidence And Severity Of Oral Mucositis In Pediatric Cancer Patients: A Systematic Review And Meta-Analysis. Supportive Care In Cancer, 30(11), 8819-8829.
Brown, J. S., Amend, S. R., Austin, R. H., Gatenby, R. A., Hammarlund, E. U., & Pienta, K. J. (2023). Updating The Definition Of Cancer. Molecular Cancer Research, 21(11), 1142-1147.
Brown, T. J., & Gupta, A. (2020). Management Of Cancer Therapy–Associated Oral Mucositis. JCO Oncology Practice, 16(3), 103-109.
Dastan, F., Ameri, A., Dodge, S., Shishvan, H. H., Pirsalehi, A., & Abbasinazari, M. (2020). Efficacy And Safety Of Propolis Mouthwash In Management Of Radiotherapy Induced Oral Mucositis; A Randomized, Double Blind Clinical Trial. Reports Of Practical Oncology & Radiotherapy, 25(6), 969-973.
Davy, C., & Heathcote, S. (2021). A Systematic Review Of Interventions To Mitigate Radiotherapy-Induced Oral Mucositis In Head And Neck Cancer Patients. Supportive Care In Cancer, 29, 2187-2202.
Dharman, S., Maragathavalli, G., Shanmugasundaram, K., & Shanmugam, R. K. (2021). A Systematic Review And Meta-Analysis On The Efficacy Of Curcumin/Turmeric For The Prevention And Amelioration Of Radiotherapy/Radiochemotherapy Induced Oral Mucositis In Head And Neck Cancer Patients. Asian Pacific Journal Of Cancer Prevention: APJCP, 22(6), 1671.
Elad, S., Cheng, K. K. F., Lalla, R. V., Yarom, N., Hong, C., Logan, R. M., & Zur, E. (2020). MASCC/ISOO Clinical Practice Guidelines For The Management Of Mucositis Secondary To Cancer Therapy. Cancer, 126(19), 4423-4431.
Elsaadany, B., Anayb, S. M., Mashhour, K., Yossif, M., & Zahran, F. H. (2024). Rebamipide Gargle And Benzydamine Gargle In Prevention And Management Of Chemo-Radiotherapy And Radiotherapy-Induced Oral Mucositis In Head And Neck Cancer Patients (Randomized Clinical Trial). BMC Oral Health, 24(1), 645.
Filippi, A., Filippi, C., & Chan, J. (2023). Clinical Guidance For Maintaining Oral Hygiene In Patients Under-Going Chemotherapy Or Radiation Therapy: A Scoping Review. Swiss Dental Journal SSO–Science And Clinical Topics, 133(6), 368-379.
Hong, C. H., Gueiros, L. A., Fulton, J. S., Cheng, K. K. F., Kandwal, A., & Galiti, D. (2019). Systematic Review Of Basic Oral Care For The Management Of Oral Mucositis In Cancer Patients And Clinical Practice Guidelines. Supportive Care In Cancer, 27, 3949-3967.
Lovoli, A. J., Turecki, L., Qiu, M. L., Khan, M., Smith, K., Yu, H., & Singh, A. K. (2023). Severe Oral Mucositis After Intensity-Modulated Radiation Therapy For Head And Neck Cancer. JAMA Network Open, 6(10), E2337265-E2337265.
Kawashita, Y., Koyama, Y., Kurita, H., Otsuru, M., Ota, Y., Okura, M., & Umeda, M. (2019). Effectiveness Of A Comprehensive Oral Management Protocol For The Prevention Of Severe Oral Mucositis In Patients Receiving Radiotherapy With Or Without Chemotherapy For Oral Cancer: A Multicentre, Phase II, Randomized Controlled Trial. International Journal Of Oral And Maxillofacial Surgery, 48(7), 857-864.
Khamverdi, Z., Farhadian, F., Khazaei, S., & Adabi, M. (2021). Efficacy Of Chitosan-Based Chewing Gum On Reducing Salivary S. Mutans Counts And Salivary Ph: A Randomised Clinical Trial. Acta Odontologica Scandinavica, 79(4), 268-274.
Patil, K., Jogigowda, S. C., Guledgud, M. V., Christopher, V. S., Doddawad, V. G., & Hutchappa, P. V. (2024). Efficacy Of Chitosan Mouthwash For Oral Mucositis: A Promising Therapeutic Approach For Head And Neck Cancer Patients Following Radiotherapy. Douleurs: Évaluation-Diagnostic-Traitement, 25(3), 160-167.
Pulito, C., Cristaudo, A., Porta, C. L., Zapperi, S., Blandino, G., Morrone, A., & Strano, S. (2020). Oral Mucositis: The Hidden Side Of Cancer Therapy. Journal Of Experimental & Clinical Cancer Research, 39, 1-15.
Ramezani, V., Ghadirian, S., Shabani, M., Boroumand, M. A., Daneshvar, R., & Saghafi, F. (2023). Efficacy Of Curcumin For Amelioration Of Radiotherapy-Induced Oral Mucositis: A Preliminary Randomized Controlled Clinical Trial. BMC Cancer, 23(1), 354.
Raza, A., Karimyan, N., Watters, A., Emperumal, C. P., Al-Eryani, K., & Enciso, R. (2022). Efficacy Of Oral And Topical Antioxidants In The Prevention And Management Of Oral Mucositis In Head And Neck Cancer Patients: A Systematic Review And Meta-Analyses. Supportive Care In Cancer, 30(11), 8689-8703.
Rout, S. R., Kar, B., Pradhan, D., Biswasroy, P., Haldar, J., Rajwar, T. K., & Rath, G. (2023). Chitosan As A Potential Biomaterial For The Management Of Oral Mucositis, A Common Complication Of Cancer Treatment. Pharmaceutical Development And Technology, 28(1), 78-94.
Samiraninezhad, N., Rezaee, M., Gholami, A., Amanati, A., & Mardani, M. (2023). A Novel Chitosan-Based Doxepin Nano-Formulation For Chemotherapy-Induced Oral Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. Inflammopharmacology, 31(5), 2411-2420.
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates Of Incidence And Mortality Worldwide For 36 Cancers In 185 Countries. CA: A Cancer Journal For Clinicians, 71(3), 209-249.
Surmelioglu, D. G., Borsoken, A. G., Kervancıoglu, G., & Hilaloglu, N. E. Y. (2022). Effect Of The Cavity Disinfectant Containing Chitosan On Dentin Bonding Strength After Radiotherapy. The Journal Of Infection In Developing Countries, 16(10), 1602-1606.
Zhang, S., Li, J., Zhang, Y., Li, X., Zhang, Y., Li, Y., & Hu, X. (2024). Efficacy Of Nonpharmacological Interventions For Severe Radiation‐Induced Oral Mucositis Among Head And Neck Cancer Patients: A Network Meta‐Analysis Of Randomised Controlled Trials. Journal Of Clinical Nursing, 33(6), 2030-2049.
Zhang, Z., Tian, L., Liu, J., Jiang, H., & Wang, P. (2024). Evidence Summary On Managing Radiotherapy-Induced Oral Mucositis In Patients With Head And Neck Cancer. Asia-Pacific Journal Of Oncology Nursing, 11(3), 100386.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Holistik Jurnal Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
