Efek ekstrak kombinasi brokoli dan pegagan (brogandi) terhadap kualitas tidur lansia
DOI: https://doi.org/10.33024/hjk.v20i3.2852
Brokoli Kualitas Tidur Lansia Pegagan
Abstract
Background: Sleep quality tends to decline with age, and sleep disorders are common among the elderly. Poor sleep quality in the elderly can negatively impact physical health, cognitive function, and overall quality of life. Herbal-based interventions are increasingly being developed as safer alternatives to pharmacological therapy. Broccoli (Brassica oleracea var. italica) contains sulforaphane, a compound with antioxidant activity, while gotu kola (Centella asiatica) is known to have neuroprotective and anxiolytic effects that could potentially help improve sleep quality.
Purpose: To determine the effect of a combination of broccoli and pegagan extracts in improving sleep quality in the elderly.
Method: This study used a quasi-experimental design with a pretest–posttest approach with a control group. Therefore, the study was conducted at Griya Lansia Garut, West Java. However, 36 elderly people were selected using a purposive sampling technique and divided into an intervention group and a control group (18 respondents each). However, the intervention group was given a combination supplement of broccoli and pegagan extract (brogandi) at a dose of 500 mg per capsule, four capsules per day for six weeks. Then, sleep quality was measured using the pittsburgh sleep quality index (PSQI). Furthermore, data analysis was performed using the wilcoxon signed-rank test.
Results: The intervention group showed a significant improvement in sleep quality. The mean PSQI score decreased from 9.06±2.07 to 5.44±1.25 (Z = −3.65: p<0.001). In contrast, the control group showed no significant change (p = 0.317).
Conclusion: The combination of broccoli (brassica oleracea) and pegagan (centella asiatica) extracts is effective in improving sleep quality in the elderly and has the potential to be an alternative non-pharmacological intervention to overcome sleep disorders in the elderly population.
Suggestion: Develop a study related to the use of a combination of broccoli (brassica oleracea) and pegagan (centella asiatica) extracts with a larger sample size and a longer intervention period in order to obtain a more comprehensive picture of its effectiveness in improving sleep quality in the elderly.
Keywords: Broccoli; Elderly; Gotu Kola; Sleep Quality.
Pendahuluan: Kualitas tidur cenderung menurun seiring bertambahnya usia, dan gangguan tidur sering dialami oleh lansia. Kemudian, kualitas tidur yang buruk pada lansia dapat berdampak negatif terhadap kesehatan fisik, fungsi kognitif, serta kualitas hidup secara keseluruhan. Intervensi berbasis herbal mulai banyak dikembangkan sebagai alternatif yang lebih aman dibandingkan terapi farmakologis. brokoli (brassica oleracea var. italica) mengandung senyawa sulforaphane yang memiliki aktivitas antioksidan, sedangkan pegagan (centella asiatica) diketahui memiliki efek neuroprotektif dan ansiolitik yang berpotensi membantu meningkatkan kualitas tidur.
Tujuan: Untuk mengetahui efek kombinasi ekstrak brokoli dan pegagan dalam meningkatkan kualitas tidur pada lansia.
Metode: Penelitian ini menggunakan desain quasi-eksperimen dengan pendekatan pretest–posttest dengan kelompok kontrol, dilakukan di Griya Lansia Garut, Jawa Barat. Sebanyak 36 lansia dipilih menggunakan teknik purposive sampling dan dibagi menjadi kelompok intervensi dan kelompok kontrol (masing-masing 18 partisipan). Kelompok intervensi diberikan suplemen kombinasi ekstrak brokoli dan pegagan (brogandi) dengan dosis 500 mg per kapsul sebanyak 4 kapsul per hari selama 6 minggu. Kualitas tidur diukur menggunakan pittsburgh sleep quality index (PSQI) dan analisis data dilakukan menggunakan uji wilcoxon signed-rank.
Hasil: Kelompok intervensi menunjukkan peningkatan kualitas tidur yang signifikan dengan rata-rata skor PSQI menurun dari 9.06±2.07 menjadi 5.44±1.25 (Z = −3.65:p<0.001). Sebaliknya, kelompok kontrol tidak menunjukkan perubahan yang signifikan (p = 0.317).
Simpulan: Kombinasi ekstrak brokoli (brassica oleracea) dan pegagan (centella asiatica) efektif dalam meningkatkan kualitas tidur pada lansia dan berpotensi menjadi alternatif intervensi nonfarmakologis untuk mengatasi gangguan tidur pada populasi lansia.
Saran: Penelitian selanjutnya dapat mengembangkan kajian terkait penggunaan kombinasi ekstrak brokoli (brassica oleracea) dan pegagan (centella asiatica) dengan jumlah sampel yang lebih besar serta waktu intervensi yang lebih panjang agar dapat memperoleh gambaran efektivitas yang lebih komprehensif terhadap peningkatan kualitas tidur pada lansia.
Kata Kunci: Brokoli; Kualitas Tidur; Lansia; Pegagan.
Downloads
References
Buysse, D. J., Reynolds III, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry research, 28(2), 193-213.
Casagrande, M., Forte, G., Favieri, F., & Corbo, I. (2022). Sleep quality and aging: a systematic review on healthy older people, mild cognitive impairment and Alzheimer’s disease. International journal of environmental research and public health, 19(14), 8457.
Fitriana, L. A., Anggadiredja, K., Setiawan, & Adnyana, I. K. (2021). Twenty weeks of Centella asiatica improved cognitive function of women elderly with dementia. In IOP Conference Series: Earth and Environmental Science, 755(1), 2064.
Fitriana, L. A., Darmawati, I., Nasution, L. A., Putri, S. T., Rohaedi, S., Anggadiredja, K., & Adnyana, I. K. (2021). Effect of Centella Asiatica and Aerobic Exercise in Older Women With Dementia: A Randomized Controlled Trial. Malaysian Journal of Medicine & Health Sciences, 17.
Fitriana, L. A., Darmawati, I., Putri, S. T., Andriyani, S., Rustiani, E., & Hazar, F. (2024). Effectiveness of Brogandi (Broccoli and Gotu Kola) on Cognitive Function among Elderly. Jurnal Pendidikan Keperawatan Indonesia, 10(1), 67-74.
Istiqomah, V., Fitriana, L. A., & Darmawati, I. (2025). The Effectiveness of Brogandi (A Combination of Broccoli and Centella Asiatica) on Cognitive Function Among Nursing Students. Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal), 11(1), 39-46.
Jiang, J., Han, R., Ren, H., Yao, Y., & Jiang, W. (2025). A review of neuroprotective properties of Centella asiatica (L.) Urb. and its therapeutic effects. Annals of Medicine, 57(1), 2559122.
Kandasamy, A., Aruchamy, K., Rangasamy, P., Varadhaiyan, D., Gowri, C., Oh, T. H., & Athinarayanan, B. (2023). Phytochemical analysis and antioxidant activity of Centella asiatica extracts: an experimental and theoretical investigation of flavonoids. Plants, 12(20), 3547.
Kaur, D., Shri, R., & Kamboj, A. (2017). Evaluation of Anti-Anxiety Effect of Brassica oleracea L. Extracts in Experimental Animals. Pharmacognosy Journal, 9(5).
Klomparens, E. A., & Ding, Y. (2019). The neuroprotective mechanisms and effects of sulforaphane. Brain Circulation, 5(2), 74-83.
Lynch, R., Diggins, E. L., Connors, S. L., Zimmerman, A. W., Singh, K., Liu, H., Talaly, P., & Fahey, J. W. (2017). Sulforaphane from broccoli reduces symptoms of autism: a follow-up case series from a randomized double-blind study. Global advances in health and medicine, 6, 2164957X17735826.
Maust, D. T., Lin, L. A., & Blow, F. C. (2019). Benzodiazepine use and misuse among adults in the United States. Psychiatric services, 70(2), 97-106.
Min, D. H., Yu, Y. B., Kim, T. H., Kim, H., & Lee, S. (2024). Pharmacological effects of pentacyclic triterpenoids isolated from Centella asiatica. Horticulture, Environment, and Biotechnology, 65(2), 189-197.
Reubun, Y. T. A., Kumala, S., Setyahadi, S., & Simanjuntak, P. (2020). Penghambatan enzim asetilkolinesterase dari ekstrak herba pegagan (Centella asiatica (l.) urb), ekstrak daun kelor (Moringa oleifera lam.) dan kombinasinya. PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), 451-458.
Sella, E., Miola, L., Toffalini, E., & Borella, E. (2023). The relationship between sleep quality and quality of life in aging: a systematic review and meta-analysis. Health psychology review, 17(1), 169-191.
Setiawan, I., Fitriana, L. A., Adnyana, I. K., Anggadiredja, K., Ufamy, N., Darmawati, I., & Cahyani, A. (2023). Centella asiatica (Indian Pennywort) Extract and Exercise Increase Brain-Derived Neurotrophic Factor Plasma, Cognition, and Physical Fitness among Menopausal Women. J. Public Health, 11, 861-868.
Siregar, S. R., Widyawati, T., & Ichwan, M. (2023). Potensi pegagan (Centella asiatica) terhadap fungsi kognitif lanjut usia. Averrous: Jurnal Kedokteran dan Kesehatan Malikussaleh, 9(1), 94-108.
Wanasuntronwong, A., Tantisira, M. H., Tantisira, B., & Watanabe, H. (2012). Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice. Journal of ethnopharmacology, 143(2), 579-585.
Yagishita, Y., Fahey, J. W., Dinkova-Kostova, A. T., & Kensler, T. W. (2019). Broccoli or sulforaphane: is it the source or dose that matters?. Molecules, 24(19), 3593.
Zitser, J., Allen, I. E., Falgàs, N., Le, M. M., Neylan, T. C., Kramer, J. H., & Walsh, C. M. (2022). Pittsburgh Sleep Quality Index (PSQI) responses are modulated by total sleep time and wake after sleep onset in healthy older adults. PloS one, 17(6), e0270095.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Holistik Jurnal Kesehatan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
