Pengaruh ekstrak kombinasi brokoli dan pegagan terhadap tingkat depresi pada lansia
DOI: https://doi.org/10.33024/hjk.v20i2.2377
Broccoli Depresi Lansia Pegagan
Abstract
Background: Depression is a common mental health issue in older adults that can reduce quality of life and the ability to perform daily activities. The treatment of depression often involves pharmacological therapy, which can lead to side effects due to polypharmacy. Therefore, safer complementary therapy interventions are needed. Broccoli (Brassica oleracea) and gotu kola (Centella asiatica) are natural ingredients with antioxidant and neuroprotective activity that have the potential to reduce the symptoms of depression.
Purpose: To assess the effect of administering a combination of broccoli and gotu kola extracts on depression levels in the elderly population.
Method: This study used a quasi-experimental design with a pretest-posttest control group approach, involving 36 elderly individuals divided into intervention and control groups. The intervention group received a combination extract of broccoli and gotu kola (2x1000mg/day) for six weeks, while the control group received no intervention. The level of depression was measured using the Geriatric Depression Scale-15 (GDS-15). Data analysis was performed using the independent samples t-test.
Results: The average depression score in the intervention group significantly decreased from 5.78 ± 3.49 to 3.61 ± 2.23 (p < 0.001). The control group did not show a significant difference in the decrease of depression scores (p = 0.079).
Conclusion: The administration of a combination of broccoli and gotu kola extract can reduce the level of depression in the elderly as a complementary therapy.
Suggestion: Research with larger samples and placebo groups, as well as measurements of biomarkers related to oxidative stress, inflammation, and neurotransmitter function.
Keywords: Broccoli; Depression; Elderly; Gotu Kola.
Pendahuluan: Depresi adalah masalah kesehatan mental umum pada lansia yang dapat menurunkan kualitas hidup dan kemampuan menjalani aktivitas sehari-hari. Penanganan depresi sering melibatkan terapi farmakologis, yang dapat menyebabkan efek samping akibat polifarmasi. Oleh karena itu, dibutuhkan intervensi terapi komplementer yang lebih aman. Brokoli (Brassica oleracea) dan pegagan (Centella asiatica) adalah bahan alami dengan aktivitas antioksidan dan neuroprotektif yang berpotensi mengurangi gejala depresi.
Tujuan: Untuk menilai pengaruh pemberian ekstrak kombinasi brokoli dan pegagan terhadap tingkat depresi pada populasi lanjut usia.
Metode: Penelitian ini menggunakan desain quasi-eksperimen dengan pendekatan pretest-posttest control group melibatkan 36 lansia yang dibagi menjadi kelompok intervensi dan kontrol. Kelompok intervensi menerima ekstrak kombinasi brokoli dan pegagan (2x1000mg/hari) selama 6 minggu, sedangkan kelompok kontrol tidak menerima intervensi. Tingkat depresi diukur dengan Geriatric Depression Scale-15 (GDS-15). Analisis data dilakukan menggunakan uji independet sample t-test.
Hasil: Skor depresi rata-rata pada kelompok intervensi menurun secara signifikan dari 5.78 ± 3.49 menjadi 3.61 ± 2.23 (p < 0.001). Kelompok kontrol tidak menunjukkan perbedaan signifikan dalam penurunan skor depresi (p = 0.079).
Simpulan: Pemberian ekstrak kombinasi brokoli dan pegagan dapat menurunkan tingkat depresi pada lansia sebagai terapi komplementer.
Saran: Penelitian selanjutnya dapat menambahkan besaran sampel dan kelompok plasebo serta pengukuran biomarker terkait stres oksidatif, inflamasi, dan fungsi neurotransmitter.
Kata Kunci: Brokoli; Depresi; Lansia; Pegagan.
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References
Alexopoulos, G. S. (2019). Mechanisms and treatment of late-life depression. Translational Psychiatry.
Aliyah, L., Permatasari, L. I., & Akbar, R. (2025). Hubungan antara activity of daily living dengan kejadian depresi pada lanjut usia. Citra Delima Scientific Journal, 8 (2), 156–167.
Anissa, M., & Abdullah, D. (2025). Patofisiologi Biomedik Depresi: Tinjauan Komprehensif terhadap Mekanisme Neurobiologis. Scientific Journal, 4(3), 177–180.
Bertollo, A. G., Mingoti, M. E. D., Medeiros, J., Silva, G. B. da, Capoani, G. T., Lindemann, H., Cassol, J. V., Manica, D., Oliveira, T., Garcez, M. L., Bagatini, M. D., Bohnen, L. C., Roman, W. A., & Ignácio, Z. M. (2024). Hydroalcoholic extract of Centella asiatica and madecassic acid reverse depressive-like behaviors , inflammation and oxidative stress in adult rats submitted to stress in early life. Molecular Neurobiology, 1–33.
Cavdar, V. C., Ballica, B., Aric, M., Karaca, Z. B., Altunoglu, E. G., & Akbas, F. (2024). Exploring depression, comorbidities and quality of life in geriatric patients: a study utilizing the geriatric depression scale and WHOQOL-OLD questionnaire. BMC Geriatrics, 24(1).
Colombage, R. L., Barfoot, K. L., & Lamport, D. J. (2025). Effects of Dietary Flavonoids on Mood and Mental Health : A Systematic Review. Nutrition Reviews, 00(00), 1–17.
Devita, M., De Salvo, R., Ravelli, A., De Rui, M., Coin, A., Sergi, G., & Mapelli, D. (2022). Recognizing depression in the elderly: practical guidance and challenges for clinical management. Neuropsychiatric disease and treatment, 2867-2880.
Diniz, B. S., Mendes-silva, A. P., Silva, L. B., Bertola, L., Vieira, C., Ferreira, J. D., Nicolau, M., Bristot, G., Dias, E., Teixeira, A. L., & Kapczinski, F. (2018). Oxidative stress markers imbalance in late-life depression. Journal of Psychiatric Research.
Fitriana, L. A., Darmawati, I., Putri, S. T., Andriyani, S., Rohaedi, S., Sulastri, A., Rustiani, E., & Hazar, F. (2024). Effectiveness of Brogandi ( Broccoli and Gotu Kola ) on Cognitive Function among Elderly. Jurnal Pendidikan Keperawatan Indonesia, 10(1), 67–74.
Ghazizadeh-Hashemi, F., Bagheri, S., Ashraf-Ganjouei, A., Moradi, K., Shahmansouri, N., Mehrpooya, M., Noorbala, A.-A., & Akhondzadeh, S. (2021). Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double-blind, placebo-controlled clinical trial. Psychiatry and Clinical Neurosciences, 250–255.
Guasch, C., Schulte, V. P., & Rojas-Velasquez, D. (2025). Association of Antidepressants and Apathy in the Geriatric Population : A Systematic Literature Review. The American Journal of Geriatric Psychiatry: Open Science, Education, and Practice, 6, 24–38.
Gunawan, I., & Huang, X. (2022). Prevalence of depression and its related factors among older adults in Indonesian nursing homes. Belitung Nursing Journal, 8(3).
Hadrianti, D., Saherna, J., Arji, A., Pratama, Z., Putri, A., & Khaliza, N. (2024). Geriatric Depression Scale (GDS) sebagai Pengkajian Status Psikologis pada Lansia. Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM), 7(3), 1236–1246.
Haller, H., Anheyer, D., Cramer, H., & Dobos, G. (2019). Complementary therapies for clinical depression : an overview of systematic reviews. BMJ.
Hidayah, N., Abidah, R. S., & Mahmudah, R. L. (2025). Faktor-Faktor Yang Berhubungan Dengan Terjadinya Depresi Pada Lansia (Literature Review). Hospital Majapahit (Jurnal Ilmiah Kesehatan Politeknik Kesehatan Majapahit Mojokerto), 17(1), 108–116.
Kementerian Kesehatan Republik Indonesia. (2018). Laporan Riskesdas Provinsi Jawa Barat 2018. In Lembaga Penerbit Badan Litbang Kesehatan. Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan (LPB). Diakses dari:https://litbang.kemkes.go.id
Kusuma, M. D. S., & Darmawati, I. D. A. A. (2025). Health Literacy dan Gejala Depresi pada Lansia di Denpasar. Jurnal Kesehatan Komunitas, 11(1), 159–166.
Margaretha, C., Sarjana, W., Suharto, & Jusup, I. (2021). Relationship between quality of life, depression, and participation in elderly integrated health service post among older adults. Nurse Media Journal of Nursing, 11(2), 144–153.
Nathalia, V., & Elvira, M. (2021). Terapi Kognitif Menurunkan Depresi Pada Lansia. Jurnal Kesehatan Perintis (Perintis’s Health Journal), 7(2), 87–91.
Nouchi, R., Hu, Q., Ushida, Y., Suganuma, H., & Kawashima, R. (2022). Effects of sulforaphane intake on processing speed and negative moods in healthy older adults : Evidence from a randomized controlled trial. Frontiers, July, 1–11.
Nurhidayati, I., Muflih, M., & Erwanto, I. (2024). Persepsi Lansia Terhadap Penggunaan Terapi Komplementer Dan Alternatif Sebagai Mitigasi Masalah Kesehatan. Jurnal Keperawatan Komplementer Holistic, 2(2), 14–23.
Ren, Q., He, C., Sun, Y., Gao, X., Zhou, Y., Qin, T., Zhang, Z., Wang, X., Wang, J., Wei, S., & Wang, F. (2024). Asiaticoside improves depressive-like behavior in mice with chronic unpredictable mild stress through modulation of the gut microbiota. Frontiers in Pharmacology, 15(October), 1–18.
Salomé, C. A., Armando, C., & Vale, N. (2023). Oxidative Stress in Depression : The Link with the Stress Response , Neuroinflammation , Serotonin , Neurogenesis and Synaptic Plasticity. Antioxidants, 12(470).
Santandreu, J., Caballero, F. F., Gomez-Serranillos, M. P., & Gonzalez-Burgos, E. (2024). Association between tricyclic antidepressants and health outcomes among older people : A systematic review and meta-analysis. Maturias, 188.
Shrestha, A., Roach, M., Joshi, K., Sheehan, J. J., Goutam, P., Everson, K., Heerlein, K., & Jena, A. B. (2020). Incremental Health Care Burden of Treatment- Resistant Depression Among Commercial , Medicaid , and Medicare Payers. Psychiatric Services, 71(6).
Sisi, N., & Ismahmudi, R. (2020). Hubungan Usia dan Jenis Kelamin dengan Tingkat Depresi pada Lansia di Posyandu Lansia Wilayah Kerja Puskesmas Wonorejo Samarinda. Borneo Student Research, 1(2), 895–900.
Subedi, L., Cho, K., Park, Y. U., Choi, H. J., & Kim, S. Y. (2019). Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation. Oxidative Medicine and Cellular Longevity, 2019.
Tang, R., Cao, Q., Hu, S., He, L., Du, P., Chen, G., Fu, R., Xiao, F., & Sun, Y. (2021). Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription. Acta Pharmacologica Sinica, 829–839.
Wang, L., Guo, T., Guo, Y., & Xu, Y. (2020). Asiaticoside produces an antidepressant ‑ like effect in a chronic unpredictable mild stress model of depression in mice , involving reversion of inflammation and the PKA / pCREB / BDNF signaling pathway. Molecular Medicine Reports, 2364–2372.
World Health Organization. (2025). Mental Health of Older Adults. Diakses dari:https://www.who.int/news-room/fact-sheets/detail/mental-health-of-older-adults
Wulandari, E., Nasution, R. A., & Sari, Y. I. P. (2023). Hubungan Kualitas Tidur dengan Fungsi Kognitif Lansia di Puskesmas Muara Kumpe. Jurnal Ilmiah Ners Indonesia, 4(1), 134–144.
Zhao, R., Wang, J., Kim, S., & Xu, B. (2025). New Insights Into Anti-Depression Effects of Bioactive Phytochemicals. Pharmacological Research, 212
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