Multidimensional determinants of family compliance in childhood tuberculosis treatment: A scoping review
DOI: https://doi.org/10.33024/hjk.v19i11.1878
Childhood Family Compliance Multidimensional Determinants Tuberculosis
Abstract
Background: Tuberculosis (TB) in children remains a significant global health problem. Family non-adherence to treatment is a major challenge hindering successful therapy.
Purpose: To identify and analyze determinants associated with family attendance during tuberculosis (TB) treatment in children.
Method: This scoping review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) framework. A systematic literature search was conducted in PubMed, Scopus, Science Direct, and Google Scholar databases using relevant keywords. Articles meeting the inclusion criteria were assessed for quality using the Joanna Briggs Institute (JBI) critical appraisal tool.
Results: Family adherence factors were grouped into two main groups: internal factors (such as family knowledge, attitudes, perceptions, and motivation) and external factors (such as support from healthcare professionals, quality of care, socioeconomic conditions, and medication accessibility). These two factors are interrelated and influence children's treatment.
Conclusion: These findings provide insight that interventions to achieve adherence should not be a single approach. A comprehensive strategy is needed that integrates health education, strengthening psychosocial support, and increasing access to services to support the family's role as treatment advocates.
Keywords: Childhood; Family Compliance; Multidimensional Determinants; Tuberculosis.
Pendahuluan: Tuberkulosis (TBC) pada anak masih menjadi masalah kesehatan global yang signifikan. Ketidakpatuhan keluarga dalam pengobatan menjadi salah satu tantangan utama yang menghambat keberhasilan terapi.
Tujuan: Untuk mengidentifikasi dan menganalisis faktor-faktor determinan yang berhubungan dengan kepatuhan keluarga selama pengobatan tuberkulosis (TBC) anak.
Metode: Penelitian scoping review ini dilakukan dengan mengikuti kerangka kerja preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR). Pencarian literatur dilakukan secara sistematis pada database PubMed, Scopus, Science Direct, dan Google Scholar dengan menggunakan kata kunci yang relevan. Artikel yang memenuhi kriteria inklusi dinilai kualitasnya menggunakan perangkat penilaian kritis joanna briggs institute (JBI).
Hasil: Faktor kepatuhan keluarga dikategorikan menjadi dua kelompok utama, yaitu faktor internal (seperti pengetahuan, sikap, persepsi, dan motivasi keluarga) dan faktor eksternal (seperti dukungan tenaga kesehatan, kualitas layanan, kondisi sosial-ekonomi, dan aksesibilitas obat). Kedua kelompok faktor ini saling berkaitan dalam memengaruhi keberlanjutan pengobatan anak.
Simpulan: Temuan ini memberikan wawasan bahwa intervensi untuk meningkatkan kepatuhan tidak boleh bersifat tunggal. Diperlukan strategi komprehensif yang mengintegrasikan edukasi kesehatan, penguatan dukungan psikososial, dan perbaikan akses layanan untuk mendukung peran keluarga sebagai pendamping minum obat (PMO).
Kata Kunci: Childhood; Family Compliance; Multidimensional Determinants; Tuberculosis.
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References
Amelia, A. (2025). Analisis Determinan Kepatuhan Program Minum Obat pada Pasien Tuberkulosis. Assyifa: Jurnal Ilmu Kesehatan, 1(1), 8-20.
Appiah, M. A., Arthur, J. A., Gborgblorvor, D., Asampong, E., Kye-Duodu, G., Kamau, E. M., & Dako-Gyeke, P. (2023). Barriers to tuberculosis treatment adherence in high-burden tuberculosis settings in Ashanti region, Ghana: a qualitative study from patient’s perspective. BMC Public Health, 23(1), 1317.
Arksey, H., & O’Malley, L. (2005). Scoping studies: towards a methodological framework. International Journal of Social Research Methodology, 8(1), 19–32.
Chatterjee, S., Das, P., Stallworthy, G., Bhambure, G., Munje, R., & Vassall, A. (2024). Catastrophic costs for tuberculosis patients in India: Impact of methodological choices. PLOS global public health, 4(4), e0003078.
Fekadu, G., Bekele, F., Bekele, K., Girma, T., Mosisa, G., Gebre, M., ... & Diriba, A. (2020). Adherence to anti-tuberculosis treatment among pediatric patients at nekemte specialized hospital, Western Ethiopia. Patient preference and adherence, 1259-1265.
Kumah, A. (2025). Building community networks and engagement for effective TB case management. Frontiers in Public Health, 13, 1576875.
Lutfian, L., Azizah, A., Wardika, I. J., Wildana, F., Maulana, S., & Wartakusumah, R. (2025). The role of family support in medication adherence and quality of life among tuberculosis patients: A scoping review. Japan Journal of Nursing Science, 22(1), e12629.
Melizza, N. (2018). Pengaruh Intervensi Supportive Educative System Berbasis Integrasi Self Care dan Family Centered Nursing Model Terhadap Dukungan Keluarga Dalam Meningkatkan Status Gizi Penderita Tuberkulosis. Diakses dari: https:// repository.unair.ac.id/eprint/7703/0/
Munedzimwe, F., Chetty-Makkan, C. M., Mukora, R., Charalambous, S., Turner, K., & Chihota, V. (2023). “It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives. BMC health services research, 23(1), 1415.
Muninggar, J. (2024). BAB 5 Penyakit Tidak Menular Pada Anak. Ilmu Kesehatan Anak, 58.
Ngari, M. M., Mberia, J. K., Kanana, E., Sanga, D., Ngari, M. K., Nyagah, D. N., & Abdullahi, O. A. (2025). Mortality and loss to follow-up among Tuberculosis patients on treatment in Meru County, Kenya: a retrospective cohort study. PLOS Global Public Health, 5(3), e0003896.
Nursasi, A. Y., & Sartika, S. (2025). The Effect of “Caregiver Care for Tuberculosis Program” on Improving Knowledge, Attitudes, and Skills in Caring for Children with Tuberculosis. Indonesian Contemporary Nursing Journal (indones. contemp. nurs. j.), 10(1), 69-80.
Pratiwi, Q. A., Sulistyorini, L., & Kurniawati, D. (2021). The Relationship of the Family Role as a Medication Supervisor with Medication Adherence in Children with Pulmonary Tuberculosis in Jember City Area. NHSJ Nurs Heal Sci J, 1(2), 154-8.
Putra, K. W. R., & Toonsiri, C. (2019). Factors related to the successful treatment of tuberculosis: A literature review. Belitung Nursing Journal, 5(4), 136-146.
Rodríguez-Márquez, I., Benjumea-Bedoya, D., Restrepo-Gouzy, A. V., Beltrán-Arroyave, C. P., Marín, D., Montes-Zuluaga, F. N., & Robledo, J. (2025). Adherence to treatment for tuberculosis infection in children using a comprehensive care strategy: a prospective cohort study with a historical control group. The Lancet Regional Health–Americas, 46.
Rukmini, R., Mahmudah, M., Notobroto, H. B., Andarwati, P., Nantabah, Z. K., Laksono, A. D., & Lolong, D. B. (2025). Prevalence and Socioeconomic Determinants of Tuberculosis Among Children in Indonesia: Findings from the 2023 Indonesian Health Survey. Indian Journal of Tuberculosis.
Saidi, S. S., & Abdul Manaf, R. (2023). Effectiveness of family support health education intervention to improve health-related quality of life among pulmonary tuberculosis patients in Melaka, Malaysia. BMC pulmonary medicine, 23(1), 139.
Shah, V., Murugan, Y., Patel, S. S., Trivedi, N. S., Pithadiya, D., Makwana, N., & Parmar, D. (2024). Nutritional Supplementation in Tuberculosis Treatment: A Mixed Methods Study of Clinical Outcomes and Patient Perceptions in Jamnagar, India. Cureus, 16(9).
Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., & Straus, S. E. (2018). PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Annals of internal medicine, 169(7), 467-473.
World Health Organization. (2022). Operational handbook on tuberculosis. Diakses dari: https://scholar.google.com/who- operational-handbook-on-tuberculosis
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