Pengaruh ekstrak bunga pepaya (Carica papaya L.) terhadap kadar SGOT dan SGPT tikus Sprague Dawley jantan yang diberi diet tinggi lemak
DOI: https://doi.org/10.56922/chi.v3i3.4394
Carica Papaya Flower Extract NAFLD SGOT SGPT
Abstract
Background: Non-alcoholic fatty liver disease (non-alcoholic fatty liver disease / NAFLD) is one of the diseases often found in hepatology. Patients with NAFLD will experience elevated levels of Glutamic Oxaloacetic Transaminase (SGOT) and Glutamic Pyruvic Transaminase (SGPT) Serum, these events can be reduced by improving lipid profiles and liver damage due to free radicals. Papaya flowers contain flavonoids and tannins which is can inhibit fatty liver accumulation and reduce cholesterol.
Purpose: The purpose of this study was to determine the effects of papaya flower extract on serum SGOT and SGPT levels in rats fed a high-fat diet.
Method: This experimental design with true experiment, with a sample of 25 male Sprague dawley strains (Rattus norvegicus) which were divided into 5 groups, the control group was the group given the standard diet, the negative control group was only given a high-fat diet and treatment group 1 to treatment 3 was a group that was given a high-fat diet and papaya flower extract with different doses (31mg / 100grBB, 62mg / 100grBB, and 125mg / 100grBB).
Results: The results of paired T-test and One Way ANOVA analysis showed a decrease in SGOT levels at doses of 32 and 64 m / 100 grBB and decreased SGPT levels at doses of 32 mg, 64 mg, and 125 mg / 100 grBB (p <0.05). Giving papaya flower extract can reduce SGOT and SGPT levels significantly (p <0.05).
Conclution: The Conclusion from this study are that given carica papaya flower extract can lower SGOT and SGPT in the serum of rats.
Downloads
References
Ayoola, P. B., & Adeyeye, A. (2010). Phytochemical and nutrient evaluation of Carica papaya (pawpaw) leaves. International Journal of Recent Research and Applied Studies, 5(3), 325–328.
Departemen Kesehatan Republik Indonesia. (2017). Pharmaceutical Care pada Penyakit Hati. Bina Farmasi komunitas dan Klinik. Jakarta
Dharmayanti, A. W. S. (2012). Pengaruh stresor renjatan listrik pada kadar kolesterol total pada serum tikus jantan (Rattus norvegicus) strain Wistar. Stomatognatic – Jurnal Kedokteran Gigi, 9(1), 54–57.
Hasan, I. (2006). Perlemakan hati non alkoholik. Dalam A. W. Sudoyo, B. Setyohadi, I. Alwi, M. Simadibrata K., & S. Setiati (Ed.), Buku ajar ilmu penyakit dalam (Edisi ke-4, hlm. 464–472). Pusat Penerbitan Departemen Ilmu Penyakit Dalam FKUI.
Mahatriny, N. N., Payani, N. P. S., Oka, I. B. M., & Astuti, K. W. (2014). Skrining fitokimia ekstrak etanol daun pepaya (Carica papaya L.) yang diperoleh dari daerah Ubud, Kabupaten Gianyar, Bali. Jurnal Farmasi Udayana, 3(1), 8–13. https://doi.org/10.24843/JFU.2014.v03.i01.p03
Puspasari, A. F., Agustini, S. M., & Illahika, A. P. (2016). Pengaruh ekstrak daun kersen (Muntingia calabura L.) terhadap profil lipid mencit putih (Mus musculus) jantan yang diinduksi minyak jelantah. Saintika Medika, 12(1), 49–55. https://doi.org/10.22219/sm.v12i1.5260
Ratnasari, N., Senorita, H., Adie, R. H., Bayupurnama, P., Maduseno, S., & Nurdjanah, S. (2012). Non-alcoholic fatty liver disease related to metabolic syndrome: A case-control study. The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 13(1), 8–13. https://doi.org/10.24871/13120128-13
Singh, A., Bhat, T. K., & Sharma, O. P. (2011). Clinical biochemistry of hepatotoxicity. Journal of Clinical Toxicology, S4, S4:001. https://doi.org/10.4172/2161-0495.S4-001
Tangkumahat, F. G., Rorong, J. A., & Ftimah, F. (2017). Pengaruh pemberian eksttrak bunga dan daun pepaya (Carica papaya L.) terhadap kadar glukosa darah tikus wistar (Rattus norvegicus L.) yang hiperglikemik. Jurnal Ilmiah Sains, 17(2), 143-152.
Witosari, N., & Widyastuti, N. (2014). Pengaruh pemberian jus daun ubi jalar (Ipomoea batatas (L.) Lam) terhadap kadar kolesterol total tikus Wistar jantan (Rattus norvegicus) yang diberi pakan tinggi lemak. Journal of Nutrition College, 3(4), 638–646. https://doi.org/10.14710/jnc.v3i4.6863
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016). Global epidemiology of nonalcoholic fatty liver disease—Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology, 64(1), 73–84. https://doi.org/10.1002/hep.28431
Downloads
Published
Issue
Section
License
Copyright (c) 2026 JOURNAL OF Community Health Issues
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
